The role of proteins on fusion and fission: computer simulation of coarse-grained models (B03)

蛋白质对融合和裂变的作用：粗粒度模型的计算机模拟（B03）

• 批准号: 108216072
• 金额: --
• 依托单位: Institut für Theoretische Physik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/108216072?language=en
• 关键词: role; proteins; fusion; fission; computer

The aim of the project consists in investigating the mechanism, the structure and thermodynamics of transition states in protein-mediated collective processes that alter the membrane topology. Within the framework of coarse-grained models of lipids and proteins, we will employ advanced free-energy techniques and devise continuum models to study how pathways and rates depend on membrane tension and geometry as well as on the molecular architecture of lipids and proteins in order to identify conditions that facilitate fusion or fission.

该项目的目的是研究改变膜拓扑结构的蛋白质介导的集体过程中过渡态的机制、结构和热力学。在脂质和蛋白质的粗粒度模型的框架内，我们将采用先进的自由能技术和设计连续模型来研究途径和速率如何取决于膜张力和几何形状以及脂质和蛋白质的分子结构，以确定促进融合或裂变的条件。