Synthesis and Metabolism of Chlorophylls and Derivatives

本研究的重点是对叶绿素及其衍生物的合成和代谢进行广泛的研究。将研究细菌叶绿素-e中大环碳的生物合成来源，并研究这些分子在衰老细菌中的降解。合成研究的目标将是生产各种目标，包括3，8-二乙烯基叶绿素-a、异叶绿素-a、构象锁定的植物色动素以及一系列非平面的卟啉和绿素。还将建造稳定的邻苯三酚和腐蚀剂，目标是生产双大环。通过这一奖项，合成有机计划支持加州大学戴维斯分校化学系的凯文·M·史密斯博士的研究。史密斯博士将把他的工作重点放在对新型卟啉、叶绿素和细菌叶绿素的生物合成、分解代谢、化学和光谱的广泛研究上。叶绿素是光合作用重要过程中的催化剂，参与光的聚集和电荷分离过程。某些卟啉及其金属络合物将作为光合作用有机体中发现的叶绿素的仿生物质和具有潜在生物医学意义的分子进行研究。

The focus of this research is a broad study on the syntheses and metabolism of chlorophylls and derivatives. The biosynthetic origin of macrocyclic carbons in the bacteriochlorophyll-e will be investigated and the degradation of the molecules in senescent bacteria studied. Synthetic studies will be aimed at the production of a variety of targets including 3,8-divinylchlorophyll-a, isochlorophyll-a, a conformationally locked phytochromobilin and a series of non-planar porphyrins and chlorins. Stable phlorins and corroles will also be constructed with the goal of producing bis-macrocycles. With this award, the Synthetic Organic Program is supporting the research of Dr. Kevin M. Smith of the Department of Chemistry at the University of California, Davis. Dr. Smith will focus his work on a broad-based and wide-ranging study of the biosynthesis, catabolism, chemistry and spectroscopy of novel porphyrins, chlorophylls and bacteriochlorophylls. Chlorophylls are the catalysts in the vital process of photosynthesis and are involved in light gathering as well as the process of charge separation. Certain porphyrins and their metal complexes are to be studied as biomimics of chlorophylls found in photosynthetic organisms and as molecules with potential biomedical implications.