Nitrosyl and Nitroso Metalloporphyrins

俄克拉荷马州大学化学系的乔治·里希特-阿多博士， 由无机，生物无机和有机物计划支持 化学部根据教师早期职业发展奖 用于亚硝酰和亚硝基金属卟啉的研究。 氧化氮是 它是一种大气污染物，在一些 生物合成途径 有机亚硝基化合物可能发挥作用， 一氧化氮反应中的生理介质。 金属卟 复合物将被合成，和化学反应和模式， 将研究与金属中心的相互作用。 教育 该计划旨在让本科生参与研究，设计 涉及金属卟啉合成的实验室实验，以及 开发本科生物无机课程。 本研究的总体目标是检查 生物重要分子的合成类似物， 金属卟啉 这些由金属离子组成的分子 由氮和碳原子组成的环包围， 生物系统，并已发现与一氧化氮及其 衍生物. 一氧化氮是一种大气污染物， 亚硝基化合物是致癌物质，存在于某些食物和香烟中 抽烟 这种化学反应有可能提供更好的 理解金属卟啉与 生理系统中的一氧化氮。教育计划的重点是 本科研究和新的实验室实验的发展 以及强调无机生物学意义的课程 化学.

Dr. George Richter-Addo, Department of Chemistry, University of Oklahoma, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division under a Faculty Early Career Development Award for studies of nitrosyl- and nitroso-metalloporphyrins. Nitric oxide is an atmospheric pollutant and it plays an important role in some biosynthetic pathways. Organic nitroso compounds may play a role as physiological mediators in reactions of nitric oxide. Metalloporphyrin complexes will be synthesized, and the chemical reactions and modes of interaction with the metal centers will be investigated. The education plan is aimed at involving undergraduate students in research, designing laboratory experiments involving metalloporphyrin synthesis, and developing an undergraduate bioinorganic course. The overall goal of this research is to examine the reactions of synthetic analogues of biologically important molecules known as metalloporphyrins. These molecules, which consist of a metal ion surrounded by a ring of nitrogen and carbon atoms, are ubiquitous in biological systems and have been found to react with nitric oxide and its derivatives. Nitric oxide is an atmospheric pollutant, and organic nitroso compounds are carcinogens found in some food and in cigarette smoke. This chemistry has the potential to provide a better understanding of the role of the interactions of metalloporphyrins with nitric oxides in physiological systems. The education plan focuses on undergraduate research and the development of new laboratory experiments and courses which emphasize the biological significance of inorganic chemistry.