Redox Behavior of Heme-NO Models: A Vehicle for Outreach and Discovery

Heme-NO 模型的氧化还原行为：推广和发现的工具

• 批准号: 0911537
• 负责人: George Richter-Addo
• 金额: $ 63万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911537&HistoricalAwards=false
• 关键词: Redox; Behavior; Heme; NO; Models

This Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor George Richter-Addo at the University of Oklahoma and Professor Michael Shaw at Southern Illinois University at Edwardsville to determine the electrochemical behavior of metalloporphyrins containing the NO ligand. Both the NO molecule and metalloporphyrins (e.g., the heme group in the liver enzyme cytochrome P450) are biochemically relevant and undergo electron-transfer reactions. However, the effects of the NO ligand on the electron transfer properties of metalloporphyrins are not well understood. New and innovative spectroelectrochemical methodologies are being developed to provide, for the first time, the needed spectral data for complete characterization of important intermediates to gain insight on the location of electron addition and removal, and to determine the fate of the redox-generated intermediates.Electrochemistry is being used in this work as a tool to inculcate the broader community with fundamental concepts in chemistry in a way that brings chemistry into the home. The research and instructional outreach programs extend to communities in East St. Louis and to Langston University that have large numbers of underrepresented minority populations, and to K-12 home schooled students and their parents. Students involved in this project develop a mature understanding of modern electrochemical methods and issues which prepare them for careers in fields which involve the interaction of chemistry with electrodes, including modern batteries, fuel cells, and photocells. Knowledge of how electrochemistry provides insight into the chemical properties of materials is essential to a broader understanding of how nature utilizes electron transfer for critical processes such as photosynthesis and respiration.

无机，生物无机和有机化学计划的这项研究奖支持俄克拉荷马州大学的乔治里希特-阿多教授和爱德华兹维尔南伊利诺伊大学的迈克尔·肖教授的工作，以确定含有NO配体的金属卟啉的电化学行为。 NO分子和金属卟啉（例如，肝酶细胞色素P450中的血红素基团）在生物化学上是相关的，并经历电子转移反应。 然而，NO配体对金属卟啉的电子转移性质的影响还没有得到很好的理解。 正在开发新的和创新的光谱电化学方法，以首次提供重要中间体的完整表征所需的光谱数据，以了解电子添加和去除的位置，并确定氧化还原的结果电化学在这项工作中被用作一种工具，以一种方式向更广泛的社区灌输化学中的基本概念，把化学带入家庭。 研究和教学推广计划延伸到东圣路易斯的社区和兰斯顿大学，这些社区有大量代表性不足的少数民族人口，以及K-12家庭教育的学生和他们的父母。 参与该项目的学生对现代电化学方法和问题有了成熟的理解，这些方法和问题为他们在涉及化学与电极相互作用的领域的职业生涯做好了准备，包括现代电池，燃料电池和光电池。 了解电化学如何深入了解材料的化学性质，对于更广泛地了解自然界如何利用电子转移进行光合作用和呼吸等关键过程至关重要。