CRIF:MU Hardware and Cyberinfrastructure Update of a 400 MHz NMR

凭借化学研究仪器和设施：多用户计划(CRIF：MU)颁发的这一奖项，俄克拉荷马大学化学和生物化学系将升级一台400 MHz核磁共振光谱仪。升级后的光谱仪将用于以下研究项目：1)无机活性硫物种；2)血浆中致动脉粥样硬化氧化剂的分配动力学模型；3)α-突触核蛋白相关细胞毒性的天然产物调节；4)有机和分子装置：双稳[2]环烷的异构化；5)过渡金属介导的碳氢化合物的氮化反应；6)过渡金属-聚咪唑络合物的仿生化学；以及7)脂磷壁酸的结构和动力学。几个地区的学院和大学的学生将通过网络基础设施的升级来远程访问和控制该仪器。核磁共振光谱是化学家可以用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities: Multi User program (CRIF:MU), the Department of Chemistry and Biochemistry at the University of Oklahoma will upgrade a 400 MHz NMR spectrometer. The upgraded spectrometer will be utilized in research projects including 1) inorganic reactive sulfur species, 2) kinetic model for the partitioning of atherogenic oxidants in plasma, 3) natural product modulation of a-synuclein-related cellular toxicity, 4) organic and molecular devices:isomerization of bistable [2]catenanes, 5) transition metal-mediated nitrogenation of hydrocarbons, 6) biomimetic chemistry of transition metal-poly(imidazole) complexes, and 7) lipoteichoic acid structure and dynamics. Students at several area colleges and universities will be access and control the instrument remotely via a cyberinfrastructure upgrade.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.