Free Radical Chain Reactions

本研究的重点是设计综合适用， 区域选择性和立体选择性自由基链过程。 一 方法将涉及提高各种激进的效率， 过程通过催化作用，并尽可能消除 需要外部试剂。 第二个感兴趣的领域是控制 通过使用自由基阳离子的区域选择性和立体选择性 和溶剂效应。 第三，β-氧基团在 将探测非对映选择性自由基反应。 随着这次续约 奖，合成有机计划是支持博士的研究。 伊利诺伊大学化学系的大卫克里奇说， 在芝加哥。 克里奇教授将把工作重点放在三个方面， 自由基化学，即自由基链式反应的催化， 涉及自由基阳离子和非对映选择性自由基的链式过程 反应. 这些基础性的研究将引导反应的发展 对合成化学家有巨大潜在用途的化学。

The focus of this research is to design synthetically applicable, regioselective and stereoselective radical chain processes. One approach will involve improvement of the efficiency of various radical processes through catalysis and, whenever possible elimination of the need for external reagents. A second area of interest is the control of regioselectivity and stereoselectivity through the use of radical cations and solvent effects. Thirdly, the effect of beta-oxygen groups in diastereoselective radical reactions will be probed. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. David Crich of the Department of Chemistry at the University of Illinois at Chicago. Professor Crich will focus his work on three aspects of free radical chemistry, namely catalysis of radical chain reactions, chain processes involving radical cations and diastereoselective radical reactions. These basic studies will lead to the development of reaction chemistry of great potential use to synthetic chemists.