U.S.-France Cooperative Research: Asymmetric Induction in Radical Cyclizations

这个为期三年的奖项支持芝加哥伊利诺伊大学的大卫·克里奇和艾克斯马赛第三大学的米歇尔·伯特兰在有机合成方面的美法合作研究。本研究涉及自由基化学的合成应用，主要通过一系列实验来探索、理解和应用自由基环化反应在不对称合成中的应用。研究人员将合成多种碳-碳二烯酸酯并鉴定它们的环化反应。通过磺酰基加成烯烃引起的自由基环化也将被研究。这位美国研究者为这次合作带来了新的自由基链式反应的设计及其在复杂分子合成中的应用方面的专业知识。他们将继续研究酰基自由基及其环化反应以及非对映选择自由基在碳水化合物化学中的应用。法国研究人员对磺酰基环化的研究补充了这一点。近年来，自由基环化反应得到了广泛的研究，现已应用于有机合成中。研究者提出的大环化尚未得到研究。本研究结果可能导致新技术，为新材料和天然产物的设计合成提供基础。

This three-year award supports U.S.-France cooperative research in organic synthesis between David Crich of the University of Illinois at Chicago, and Michelle Bertrand of the University of Aix Marseille III. The research involves synthetic applications of radical chemistry and focuses on a series of experiments to probe, understand and apply radical cyclization reactions in asymmetric synthesis. The investigators will synthesize a variety of carbon-carbon dienyl acetates and identify their cyclization reactions. Radical cyclizations induced through the addition of sulfonyl to alkenes will also be studied. The U.S. investigator brings to this collaboration expertise in the design of new free radical chain reactions and their application to the synthesis of complex molecules. They will continue to work on acyl radicals and their cyclizations reactions and the used of diastereoselection radical reactions in carbohydrate chemistry. This is complemented by the French investigators' work on the study of sulfonyl radical cyclizations. Radical cyclizations have been extensively studied in recent years and are now employed in organic synthesis. Macrocyclizations, which is addressed by the investigators, have not been studied. Results of this research may lead to new techniques that provide the basis for designed synthesis of new materials and natural products.