U.S.-France Cooperative Research: Asymmetric Induction in Radical Cyclizations

这项为期三年的奖项支持伊利诺伊大学芝加哥分校的David Crich和艾克斯·马赛大学的Michelle Bertrand在有机合成方面的美法合作研究。这项研究涉及自由基化学的合成应用，并专注于一系列实验，以探索、理解和应用不对称合成中的自由基环化反应。研究人员将合成各种碳-碳二烯基乙酸酯，并鉴定它们的环化反应。还将研究通过将磺酰加到烯烃中而引起的自由基环化反应。这位美国研究人员将设计新的自由基链反应及其在复杂分子合成中的应用方面的专业知识带到了这次合作中。他们将继续致力于酰基及其环化反应，以及碳水化合物化学中非对映选择自由基反应的使用。这与法国研究人员在研究磺酰自由基环化反应方面的工作是相辅相成的。自由基环化反应近年来得到了广泛的研究，现已应用于有机合成中。研究人员解决的大环化作用还没有被研究过。这项研究的结果可能导致新的技术，为新材料和天然产品的设计性合成提供基础。

This three-year award supports U.S.-France cooperative research in organic synthesis between David Crich of the University of Illinois at Chicago, and Michelle Bertrand of the University of Aix Marseille III. The research involves synthetic applications of radical chemistry and focuses on a series of experiments to probe, understand and apply radical cyclization reactions in asymmetric synthesis. The investigators will synthesize a variety of carbon-carbon dienyl acetates and identify their cyclization reactions. Radical cyclizations induced through the addition of sulfonyl to alkenes will also be studied. The U.S. investigator brings to this collaboration expertise in the design of new free radical chain reactions and their application to the synthesis of complex molecules. They will continue to work on acyl radicals and their cyclizations reactions and the used of diastereoselection radical reactions in carbohydrate chemistry. This is complemented by the French investigators' work on the study of sulfonyl radical cyclizations. Radical cyclizations have been extensively studied in recent years and are now employed in organic synthesis. Macrocyclizations, which is addressed by the investigators, have not been studied. Results of this research may lead to new techniques that provide the basis for designed synthesis of new materials and natural products.