U.S.-France Cooperative Research: Asymmetric Induction in Radical Cyclizations

这个为期三年的奖项支持美国-法国合作研究 在有机合成方面， 伊利诺斯州芝加哥大学的米歇尔·伯特兰和 艾克斯马赛III. 这项研究涉及合成应用的 自由基化学，并侧重于一系列的实验， 探索、理解和应用自由基环化反应， 不对称合成 研究人员将综合各种 的碳-碳二烯基乙酸酯，并确定其环化 反应.通过加成引发的自由基环化反应 还将研究磺酰基到烯烃的转化。 美国调查员 带来了这种合作的专业知识，在设计新的免费 自由基链式反应及其在合成 复杂分子 他们将继续研究酰基自由基 以及它们的环化反应和非对映选择的应用 碳水化合物化学中的自由基反应。 这是 法国研究人员的研究工作， 磺酰基自由基环化。 近年来自由基环化反应得到了广泛的研究 现在用于有机合成。 大环化， 这是由调查人员解决的，还没有被研究。 这项研究的结果可能会导致新的技术， 设计合成新材料和天然 产品.

This three-year award supports U.S.-France cooperative research in organic synthesis between David Crich of the University of Illinois at Chicago, and Michelle Bertrand of the University of Aix Marseille III. The research involves synthetic applications of radical chemistry and focuses on a series of experiments to probe, understand and apply radical cyclization reactions in asymmetric synthesis. The investigators will synthesize a variety of carbon-carbon dienyl acetates and identify their cyclization reactions. Radical cyclizations induced through the addition of sulfonyl to alkenes will also be studied. The U.S. investigator brings to this collaboration expertise in the design of new free radical chain reactions and their application to the synthesis of complex molecules. They will continue to work on acyl radicals and their cyclizations reactions and the used of diastereoselection radical reactions in carbohydrate chemistry. This is complemented by the French investigators' work on the study of sulfonyl radical cyclizations. Radical cyclizations have been extensively studied in recent years and are now employed in organic synthesis. Macrocyclizations, which is addressed by the investigators, have not been studied. Results of this research may lead to new techniques that provide the basis for designed synthesis of new materials and natural products.