One and Two Electron Approaches to Glycoside Synthesis

本研究的重点是两种方法的发展 用于制备具有环己基的赤道糖苷键， 强调1，2-顺式-赤道键和2-脱氧-赤道键。 两种方法，一种涉及自由基，分子内 氢提取和另一个涉及铜离子 促进吡啶甲酸糖基酯的取代，依赖于 在容易制备的轴向异构体的异头中心处的反转 异构体。 %%% 有了这个奖项，合成有机计划正在支持 化学系的大卫克里奇博士的研究 在芝加哥的伊利诺伊大学。 克里奇教授将 将他的工作集中在寡糖部分的合成上， 糖蛋白 这些蛋白质参与了 从酶，激素， 抗体和凝集素通过细胞-细胞识别。

The focus of this research is the development of two methods for the preparation of equatorial glycosidic linkages with an emphasis on 1,2-cis-equatorial and 2-deoxy-equatorial linkages. Both approaches, one involving free radical, intramolecular hydrogen abstraction and the other involving copper ion promoted substitution of picolinate glycosyl esters, rely on inversion at the anomeric center of a readily prepared axial isomer. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. David Crich of the Department of Chemistry at the University of Ilinois at Chicago. Professor Crich will focus his work on the synthesis of the oligosaccharide portion of glycoproteins. These proteins are implicated in processes ranging from the binding and transport of enzymes, hormones, antibodies and lectins through cell-cell recognition.