Bond Making and Bond Breaking Processes at Transition Metal Centers

过渡金属中心的成键和断键过程

• 批准号: 9625367
• 负责人: Edward Rosenberg
• 金额: $ 26.2万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9625367&HistoricalAwards=false
• 关键词: Bond; Making; Breaking; Processes; Transition

With this award, the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on transition metal quinoline complexes by Dr. Edward Rosenberg of the Chemistry Department, University of Montana. First, the synthesis and mechanism of carbon-carbon bond-forming during nucleophilic addition to transition metal-activated quinolines will be investigated. Some triosmium quinoline complexes undergo nucleophilic addition regio- and stereoselectively at the 5-position of the quinoline ring. This reaction will be exploited for potential applications in organic synthesis. Carbon-nitrogen bond cleavage in quinoline derivatives complexed to polymetallic sites will also be studied. The products of successive hydrogenations will be determined. In a third project, kinetic isotope methods will be used to determine factors controlling hydrogen transfer to and from metals in stoichiometric and catalytic processes. Proton barrier tunneling will be considered as a possible pathway. This project is relevant to catalysis, natural product synthesis, and fuels upgrading. New methods for forming carbon bonds to quinoline could be applicable to the synthesis of neurotransmitter agonists or cytotoxic compounds. Investigation of the behavior of carbon-nitrogen bonds during hydrogenation may provide insight into the hydrodenitrogenation catalysis reaction, which is important to the petroleum industry.

有了这个奖项，无机，生物无机和有机物 化学计划支持过渡金属喹啉的研究 爱德华·罗森伯格博士的化学系，大学 蒙大拿州。 一、碳-碳的合成及机理 在亲核加成过程中与过渡金属活化 将研究喹啉。 某些三锇喹啉配合物 进行亲核加成，区域和立体选择性地在 5-喹啉环的位置。 该反应将被用于 在有机合成中的潜在应用。 碳-氮键 与多金属位点络合的喹啉衍生物的裂解将 也被研究。 连续氢化的产物将是 测定 在第三个项目中，将使用动力学同位素方法， 确定控制氢转移到金属和从金属转移的因素， 化学计量和催化过程。 质子势垒隧穿将是 被认为是一种可能的途径。 该项目涉及催化、天然产物合成和 燃料升级。 与喹啉形成碳键的新方法可以 可用于合成神经递质激动剂或细胞毒性药物 化合物.碳-氮键行为的研究 氢化可以提供对氢化脱氮催化的深入了解 反应，这对石油工业很重要。