Acquisition of a 500 MHz NMR spectrometer

蒙大拿大学化学系将从主要研究仪器(MRI)计划获得这一奖项，以获得一台500 MHz的核磁共振光谱仪。该设备将使研究人员能够开展以下方面的研究：a)链霉菌的代谢工程和生物合成；b)使用氟-19核磁共振探测大分子相互作用；c)苯并杂环簇合物作为生物标志物的应用；d)逆转录病毒RNA的结构和功能的研究；e)从未受保护的碳水化合物合成羟基化聚酰胺；以及f)药物化学。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对许多领域产生影响，包括药物和聚合物化学。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at The University of Montana will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) metabolic engineering and biosynthesis in Streptomyces; b) the use of fluorine-19 NMR to probe macromolecular interactions; c) the application of triosmium benzoheterocycle clusters as biomarkers; d) studies of the structure and function of retro-viral RNA; e) synthetic hydroxylated polyamides from unprotected carbohydrates; and f) medicinal chemistry. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas, including medicinal and polymer chemistry.