New NMR Techniques Using Excitation Sculpting

使用激发雕刻的新核磁共振技术

• 批准号: 9625674
• 负责人: Athan Shaka
• 金额: $ 31.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9625674&HistoricalAwards=false
• 关键词: New; NMR; Techniques; Using; Excitation

In this project in the Experimental Physical Chemistry Program of the Chemistry Division, Shaka will develop a new pulsed nuclear magnetic resonance (NMR) technique called excitation sculpting. Strong DC magnetic pulsed field gradients (PFGs) will be used in conjunction with frequency sweeps to eliminate out-of-band signals, revealing the desired excitation profile and resulting in significant advantages compared to conventional pulse shaping. Preliminary results show effective water suppression using the new technique, in which protons bound to carbon-12 nuclei are suppressed without loss of the desired signal from protons bonded to a carbon-13. Combined with superior carbon-13 decoupling, superb high-resolution absorption-mode proton multiplets are obtained. Nuclear magnetic resonance spectroscopy is one of the most useful tools in the chemist's arsenal. Techniques are constantly being developed which allow this method to be applied to more problems, so that more information can be extracted from NMR spectra with respect to such varied systems as inorganic materials and biologically important molecules. The excitation sculpting method being developed in this work is expected to have a large impact on most important NMR experiments, including some `routine` experiments carried out in NMR facilities everywhere.

在化学系实验物理化学项目的这个项目中，沙卡将开发一种称为激发雕刻的新型脉冲核磁共振（NMR）技术。 强直流磁脉冲场梯度 (PFG) 将与频率扫描结合使用，以消除带外信号，揭示所需的激励曲线，并与传统脉冲整形相比具有显着优势。 初步结果表明，使用新技术可有效抑制水，其中与碳 12 原子核结合的质子被抑制，而不会损失与碳 13 结合的质子发出的所需信号。 结合卓越的碳 13 解耦，可以获得极好的高分辨率吸收模式质子多重态。 核磁共振波谱是化学家武器库中最有用的工具之一。 技术的不断发展使得这种方法能够应用于更多的问题，从而可以从核磁共振谱中提取关于无机材料和生物学重要分子等不同系统的更多信息。 这项工作中开发的激发雕刻方法预计将对最重要的核磁共振实验产生重大影响，包括在各地核磁共振设施中进行的一些“常规”实验。