New NMR Techniques Using Excitation Sculpting

在这个项目中，在实验物理化学计划的 化学司，沙卡将开发一种新的脉冲核磁 共振（NMR）技术称为激励雕刻。 强直流 磁脉冲场梯度（PFG）将与 频率扫描消除带外信号，揭示所需的 激励曲线，并导致与 常规脉冲整形。 初步结果显示， 抑制使用新技术，其中质子绑定到碳-12 在不损失来自质子的所需信号的情况下抑制原子核 与碳13键合 结合上级碳-13去耦， 获得了极好的高分辨率吸收模式质子多重态。 核磁共振光谱是最有用的工具之一 在化学家的武器库里。 技术在不断发展 这使得这种方法可以应用于更多的问题， 可以从NMR谱中提取关于这种变化的信息 系统作为无机材料和生物重要分子。 的 激励雕刻方法正在开发这项工作，预计 对大多数重要的NMR实验有很大的影响，包括一些 在各地的核磁共振设施中进行“常规”实验。

In this project in the Experimental Physical Chemistry Program of the Chemistry Division, Shaka will develop a new pulsed nuclear magnetic resonance (NMR) technique called excitation sculpting. Strong DC magnetic pulsed field gradients (PFGs) will be used in conjunction with frequency sweeps to eliminate out-of-band signals, revealing the desired excitation profile and resulting in significant advantages compared to conventional pulse shaping. Preliminary results show effective water suppression using the new technique, in which protons bound to carbon-12 nuclei are suppressed without loss of the desired signal from protons bonded to a carbon-13. Combined with superior carbon-13 decoupling, superb high-resolution absorption-mode proton multiplets are obtained. Nuclear magnetic resonance spectroscopy is one of the most useful tools in the chemist's arsenal. Techniques are constantly being developed which allow this method to be applied to more problems, so that more information can be extracted from NMR spectra with respect to such varied systems as inorganic materials and biologically important molecules. The excitation sculpting method being developed in this work is expected to have a large impact on most important NMR experiments, including some `routine` experiments carried out in NMR facilities everywhere.