New Techniques for NMR Studies of Structure and Dynamics in Membrane Mimetics and Paramagnetic Materials

膜模拟和顺磁材料结构和动力学的核磁共振研究新技术

• 批准号: 9632618
• 负责人: Elizabeth Komives
• 金额: $ 46.65万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9632618&HistoricalAwards=false
• 关键词: New; Techniques; NMR; Studies; Structure

In this project in the Experimental Physical Chemistry Program of the Chemistry Division, Regitze Vold will develop new techniques for the NMR study of molecular structure and dynamics of solids and ordered phases. The emphasis in these studies is on inorganic, bioinorganic, and biologically important systems. Specific projects include the investigation of novel, magnetically aligned discoidal nematic phospholipid bilayered micelles (bicelles), a multi-nuclear spin relaxation study to test models of relaxation and internal motion of membrane-associated peptides in ordered bicelles, the continuation of studies of the structure and dynamics of the mitochondrial redox cofactor Q10 (ubiquinone) in phospholipid bilayers, and magic angle spinning (MAS) experiments on paramagnetic inorganic and bioinorganic model compounds. The common theme of the experiments in this project is to extend and apply NMR spectroscopy to structural and dynamic problems in chemistry which will provide information about the binding, conformation, and dynamics of biologically relevant molecules as well as about solid transition-metal complexes. The approaches being developed in this work will help increase the impact of solid-state NMR on structural biology.

在化学部实验物理化学项目的这个项目中，Regitze Vold 将开发用于固体和有序相的分子结构和动力学研究的新技术。 这些研究的重点是无机、生物无机和生物学上重要的系统。 具体项目包括研究新型磁性排列盘状向列磷脂双层胶束（bicelles）、一项多核自旋弛豫研究，以测试有序 bicelles 中膜相关肽的弛豫和内部运动模型、继续研究磷脂中线粒体氧化还原辅因子 Q10（泛醌）的结构和动力学 顺磁性无机和生物无机模型化合物的双层和魔角旋转（MAS）实验。 该项目实验的共同主题是将核磁共振波谱扩展到化学中的结构和动力学问题，并将其应用于化学中的结构和动力学问题，这将提供有关生物相关分子的结合、构象和动力学以及固体过渡金属配合物的信息。 这项工作中开发的方法将有助于增强固态核磁共振对结构生物学的影响。