Postdoctoral Research Fellowships in Chemistry
Postdoctoral Research Fellowships in Chemistry
批准号:
9626981
负责人:
Virginia Cornish
金额:
$8.0万
依托单位:
依托单位国家:
美国
项目类别:
Fellowship Award
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-08-01 至 1999-07-31
中文摘要
弗吉尼亚·W·科尼什博士被授予美国国家科学基金会化学博士后研究奖学金。康尼什博士在彼得·G·舒尔茨教授的指导下获得了加州大学伯克利分校的博士学位。科尼什博士将在罗伯特·T·鲍尔教授的赞助下继续在麻省理工学院进行研究。这项博士后研究考察了N-帽和C-帽残基在稳定α-螺旋方面的重要性。这项工作使用遗传选择来分离N-帽和C-帽位置上具有特定残基的蛋白质,以及X射线结晶学和核磁共振光谱来表征蛋白质的三维结构。了解如何设计基因选择,以便除了设计具有新催化特性的工程蛋白质外,还可以使用这些选择来了解成功催化的要求。化学博士后研究奖学金计划被视为一个重要的基础计划,旨在拓宽新博士的知识和经验,并吸引他们在当代化学研究和教学中从事有意义的职业。
英文摘要
Dr. Virginia W. Cornish has been awarded an NSF Postdoctoral Research Fellowship in Chemistry. Dr. Cornish received the doctoral degree from the University of California at Berkeley under the supervision of Professor Peter G. Schultz. Dr. Cornish will continue research at the Massachusetts Institute of Technology under the sponsorship of Professor Robert T. Sauer. The postdoctoral research examines the importance of N- and C-cap residues in stabilizing alpha-helices. The work uses genetic selections to isolate proteins with particular residues in the N- and C-cap positions, as well as x-ray crystallography and nuclear magnetic resonance spectroscopy to characterize the three-dimensional structure of the proteins. Understanding is gained into how to design genetic selections so that in addition to engineering proteins with novel catalytic properties, one my use the selections to learn about the requirement for successful catalysis. The Postdoctoral Research Fellowships in Chemistry Program is viewed as an important infrastructural program designed to broaden the knowledge and experience of new Ph. D.s and attract them into meaningful careers in contemporary chemical research and teaching.
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依托单位:
国内基金
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