Small-Molecule Induced Protein Dimerization: Tetracycline

化学部特别项目办公室的启动补助金支持哥伦比亚大学弗吉尼亚康沃尔语教授的研究。 该研究的主题是开发地塞米松-四环素作为能够高效诱导体内蛋白质二聚化的H1-H2对化学手柄。 对高效催化剂的需求是化学的基础。 生物催化剂驱动细胞过程，化学工业依赖于催化剂来合成从药物到材料的化合物。 在这个项目中，蛋白质，这是显着的催化剂，为广泛的反应，将使用组合技术设计，这使得大量的蛋白质变体池被同时产生和筛选。 一个选择策略，这是一个直接筛选催化，并可应用于许多不同的反应类型，将开发。

This starter grant award of the Special Projects Office of the Chemistry Division supports the research of Professor Virginia Cornish at Columbia University. The theme of the research is the development of dexamethasone-tetracycline as an H1-H2 pair of chemical handles capable of inducing protein dimerization in vivo with high efficiency. The need for efficient catalysts is fundamental to chemistry. Biological catalysts drive cellular processes, and the chemical industry relies on catalysts for the synthesis of compounds ranging from pharmaceuticals to materials. In this project proteins, which are remarkable catalysts for a broad array of reactions, will be designed using combinatorial techniques, which allow large pools of protein variants to be generated and screened simultaneously. A selection strategy that is both a direct screen for catalysis and can be applied to many different reaction types, will be developed.