Molecular Recognition Using Organoboron Acids

在有机动力学项目的资助下， 圣母大学正在研究有机硼的化学性质 酸与碳水化合物异构化、膜转运、药物 传递，和作为阴离子受体。调查的主要焦点是 为了通过使用硼酸促进葡萄糖向果糖的转化， 具有高度选择性的酸。更多的努力是针对 通过使用膜转运复合物的浓度增强 对果糖有很高的选择性。 正在研究新类别的有机硼酸衍生物， 它们选择性促进葡萄糖异构化的能力， 果糖。此外，正在研究这些硼酸衍生物 作为选择性膜转运果糖的试剂， 作为药物传递载体的儿茶酚胺和阴离子的分析 受体在刘易斯酸催化反应中的作用。

With funding from the Organic Dynamics Program, Professor Smith of the University of Notre Dame is investigating the chemistry of organoboronic acids with regard to carbohydrate isomerization, membrane transport, drug delivery, and as anion receptors. The major focus of the investigation is to facilitate the conversion of glucose to fructose by using boronic acids that are highly selective. Additional efforts are directed at concentration enhancement through the use of membrane transport complexes that are highly selective for fructose. New classes of organoboronic acid derivatives are being investigated for their ability to selectively facilitate the isomerization of glucose to fructose. Further, these boronic acid derivatives are being investigated as reagents for selective membrane transport of fructose, as reagents for the analysis of catecholamines, as drug delivery vehicles, and anion receptors in Lewis acid catalysis reactions.