Carboxylate Salt Receptors

该项目探索了羧酸盐受体的各个方面，包括对特定芳香酸盐的选择性膜，膜扩散的核磁共振研究，以及细菌膜特有的二肽受体。特定于盐的液膜将允许低能量、连续和环境友好的方法将羧酸产品从其碳氢化合物原料中分离出来。脉冲场梯度核磁共振研究表明，膜扩散常数并不总是与金属阳离子的同一性无关。将对天然羧基离子载体进行研究，以确定这种影响的程度和性质。组合方法将允许鉴定选择性地与二肽的C-末端结合的分子，进而将提供万古霉素等重要抗生素的模拟物。有了这个奖，有机和高分子化学计划继续支持圣母大学布拉德利·D·史密斯教授的研究项目。史密斯教授探索了膜结合分子识别特定羧酸并与之结合的能力。这一现象之所以重要，是因为通过膜的优先传输来选择性分离特定物质具有潜在的工业应用价值。此外，还将对细菌膜和某些抗生素分子的性质有更好的了解。

This project explores various aspects of carboxylate salt receptors, including membranes selective for specific aromatic acid salts, NMR studies of membrane diffusion, and receptors for dipeptides peculiar to bacterial membranes. Salt-specific liquid membranes would allow for a low-energy, continuous, and environmentally benign method for separation of carboxylic acid products from their hydrocarbon feedstocks. Pulsed field-gradient NMR has shown that membrane diffusion constant is not always independent of the identity of the metal cation. Natural carboxylic ionophores will be studied to determine the extent and nature of this effect. Combinatorial methods will permit the identification of molecules that bind selective with the C-terminus of dipeptides that, by extension, will provide mimics for such important antibiotics as vancomycin.With this Award, the Organic and Macromolecular Chemistry Program continues support for the research project of Professor Bradley D. Smith of The University of Notre Dame. Professor Smith explores the ability of membrane-bound molecules to identify specific carboxylic acids and to bind to them. This phenomenon is important because of potential industrial applications for the selective isolation of specific substances by their preferential transport across a membrane. Additionally, a better understanding of bacterial membranes and the nature of certain antibiotic molecules will be gained.