Catalysts for Asymmetric Phosphonylation and Synthetic Applications

本研究的重点是开发醛的不对称膦化催化剂，以形成高光学纯度的α -羟基膦酰胺。此外，还将制备烯丙基羟基膦酸盐，并将该方法应用于酶抑制剂的制备。有了这个奖项，合成有机项目支持了密苏里大学圣路易斯分校化学系克里斯托弗·d·斯林博士的研究。苏林教授的工作重点是发展制备α -羟基磷酰胺的合成方法。α -羟基磷酰胺是一类具有重要生物活性的化合物。

The focus of this research is the development of catalysts for the asymmetric phosphonylation of aldehydes to form alpha-hydroxyphosphonamides of high optical purity. In addition, allylic hydroxyphosphonates will be prepared and the methodology will be applied to the preparation of enzyme inhibitors. With this award, the Synthetic Organic Program is supporting the research of Dr. Christopher D. Spilling of the Department of Chemistry at the University of Missouri, St. Louis. Professor Spilling will focus his work on the development of synthetic methodology for the preparation of alpha-hydroxyphosphonamides, a class of compounds having important biological activity.