Upgrade of a CCD-based X-Ray Diffraction Laboratory

基于 CCD 的 X 射线衍射实验室升级

• 批准号: 0420497
• 负责人: Christopher Spilling
• 金额: $ 12.66万
• 依托单位: University of Missouri-Saint Louis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-11-01 至 2007-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0420497&HistoricalAwards=false
• 关键词: Upgrade; CCD; based; Ray; Diffraction

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of Missouri in St. Louis will upgrade its CCD-based X-ray diffraction laboratory. Faculty at Washington University and St. Louis University will also have access to this resource. This equipment will enhance research in a number of areas including studies on a) the development of new copper-based radiopharmaceuticals; b) the synthesis of neutral multimetallic arrays; c) formation of bimetallaboranes containing widely differing transition metals; d) metallabenzenes and other benzenoid metallacycles; e) Si-H bond activation by electron-rich transition metal complexes; f) chemistry and biology of steroids; g) the study of electron-deficient species; h) the supramolecular chemistry of alkali metal cations; and i) the synthesis of organometallic complexes with interesting optoelectronic properties. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, especially synthesis of important inorganic chemicals and medicinal chemistry.

在主要研究仪器（MRI）计划的支持下，圣路易斯密苏里州大学化学系将升级其基于CCD的X射线衍射实验室。华盛顿大学和圣路易斯大学的教师也将获得这一资源。 这一设备将加强若干领域的研究，包括以下研究：（a）开发新的铜基放射性药物;（B）合成中性多金属阵列;（c）形成含有各种不同过渡金属的双金属硼烷;（d）金属苯和其他苯型金属杂环;（e）富电子过渡金属络合物激活Si-H键;（f）类固醇的化学和生物学; g）缺电子物种的研究; h）碱金属阳离子的超分子化学;和i）具有有趣的光电性质的有机金属络合物的合成。X射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。这些研究将在许多领域产生影响，特别是重要无机化学品的合成和药物化学。