SBIR Phase I: Selective Electrochemical Fluorinations

SBIR 第一阶段：选择性电化学氟化

• 批准号: 9661396
• 负责人: Guillermo Zappi
• 金额: $ 7.5万
• 依托单位: The Electrosynthesis Company, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9661396&HistoricalAwards=false
• 关键词: SBIR; Phase; Selective; Electrochemical; Fluorinations

*** 9661396 Zappi This project addresses selective fluorination in mild conditions.. The objective of the proposed research is to demonstrate high current densities and yields in selective fluorination reactions using custom designed soluble mediators and anodically regenerated solid phase fluorinating reagents. This will constitute a generic synthetic method for the selective substitution of fluorine into aliphatic carbon atoms, and special attention will be given to the applicability of the chemistry to larger scale operation. While the applications of fluorinated drugs and specialty chemicals continue to expand, the synthetic methods for their preparation remain limited and case-specific. In most cases multi-step syntheses are required, and the overall yields are poor. A unique opportunity for the development of a new synthetic approach for the synthesis of a broad range of selectively fluorinated compounds has been identified. This method will give access to a wide range of existing compounds at more competitive prices and new compound for use in drugs, agrochemicals and other areas.

* 9661396 Zappi 该项目解决了在温和条件下的选择性脱水问题。所提出的研究的目的是展示高电流密度和产量的选择性氟化反应中使用定制设计的可溶性介质和阳极再生固相氟化试剂。这将构成一种将氟选择性取代为脂肪族碳原子的通用合成方法，并将特别关注该化学方法对更大规模操作的适用性。 虽然氟化药物和特种化学品的应用不断扩大，但其合成方法仍然有限，且因情况而异。在大多数情况下，需要多步合成，并且总产率很低。一个独特的机会，为发展一种新的合成方法，合成范围广泛的选择性氟化化合物已被确定。该方法将以更有竞争力的价格获得广泛的现有化合物和用于药物、农用化学品和其他领域的新化合物。