SBIR Phase I: Selective Electrochemical Fluorinations

*** 9661396扎皮本项目解决轻度条件下的选择性氟化问题。拟议研究的目的是在使用定制设计的可溶性介质和阳极再生固相氟化试剂的选择性氟化反应中证明高电流密度和产量。这将构成氟选择性取代成脂肪族碳原子的通用合成方法，并将特别注意化学对更大规模操作的适用性。虽然氟化药物和特种化学品的应用范围继续扩大，但制备这些药物的合成方法仍然有限，而且是根据具体情况而定。在大多数情况下，需要多步合成，总体收率很低。已经确定了开发一种新的合成方法以合成各种选择性氟化化合物的独特机会。这种方法将使人们能够以更具竞争力的价格获得广泛的现有化合物，并将新化合物用于药物、农用化学品和其他领域。

*** 9661396 Zappi This project addresses selective fluorination in mild conditions.. The objective of the proposed research is to demonstrate high current densities and yields in selective fluorination reactions using custom designed soluble mediators and anodically regenerated solid phase fluorinating reagents. This will constitute a generic synthetic method for the selective substitution of fluorine into aliphatic carbon atoms, and special attention will be given to the applicability of the chemistry to larger scale operation. While the applications of fluorinated drugs and specialty chemicals continue to expand, the synthetic methods for their preparation remain limited and case-specific. In most cases multi-step syntheses are required, and the overall yields are poor. A unique opportunity for the development of a new synthetic approach for the synthesis of a broad range of selectively fluorinated compounds has been identified. This method will give access to a wide range of existing compounds at more competitive prices and new compound for use in drugs, agrochemicals and other areas.