SBIR Phase II: A carbon selective detector for liquid phase chemical detection of organic molecules

SBIR Phase II：用于有机分子液相化学检测的碳选择性检测器

• 批准号: 1853063
• 负责人: Andrew Jones
• 金额: $ 71.42万
• 依托单位: Activated Research Company
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1853063&HistoricalAwards=false
• 关键词: SBIR; Phase; II; carbon; selective

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the potential to directly and positively impact the speed of chemical analysis leading to cleaner and more advanced products. Technology resulting from the proposed activity will solve several pain points in the chemical analysis industry, including non-linearity, small dynamic range and variable, sometimes negligible, detector response. As a result, the technology will have broad use and lead to improved detection in pharmaceuticals, drug development, fuels, chemicals, renewables, foods, flavors, and academic and industrial research. Uniform response to carbon from flame ionization detection (FID) would be completely disruptive to the painstaking methods of calibration of known compounds and the guesswork associated with the quantification of unknowns. The benefits of this technology are expected to result in immense improvements in the speed and accuracy of high-performance liquid chromatography (HPLC) analysis, thereby leading to better and safer products, with faster development times. Applied to the pharmaceutical and new drug development industry, this technology will have lasting impacts on the health and safety of society due to better and faster analyses available.This SBIR Phase II project aims to deliver a carbon selective detector (CSD) to the global scientific market. The CSD is a high-performance liquid chromatography (HPLC) detector that produces a linear response to all organic compounds using a flame ionization detection (FID) and a catalytic reactor. The key innovation is the novel development and use of a catalytic reactor to transform organic molecules and remove solvent in liquid chromatograph effluent streams. The FID, similar to those ubiquitous in gas chromatography (GC) systems, yields a universal response to organic compounds converted to methane with unparalleled linear range and robustness. The device will overcome limitations of the FID that have prevented previous use in HPLC by selectively removing solvents, oxidizing organic compounds to carbon dioxide, reducing carbon dioxide to methane, and detecting the resulting methane with the FID. The resulting product features, most notably a universal response to carbon, will provide pre-clinical pharmaceutical researchers with a tool that can quantify drugs and their by-products during screening, long before the process has been scaled up for the production of calibration standards.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业创新研究（SBIR）第二阶段项目的更广泛的影响/商业潜力是直接和积极影响化学分析速度的潜力，从而产生更清洁和更先进的产品。拟议活动产生的技术将解决化学分析行业的几个痛点，包括非线性、小动态范围和可变（有时可忽略不计）的检测器响应。因此，该技术将有广泛的用途，并导致在制药，药物开发，燃料，化学品，可再生能源，食品，香料以及学术和工业研究中改进检测。火焰离子化检测器（FID）对碳的均匀响应将完全破坏已知化合物校准的艰苦方法和与未知化合物定量相关的猜测。这项技术的好处预计将大大提高高效液相色谱（HPLC）分析的速度和准确性，从而产生更好、更安全的产品，并缩短开发时间。该技术应用于制药和新药开发行业，将对社会的健康和安全产生持久的影响，因为可以提供更好和更快的分析。SBIR第二阶段项目旨在向全球科学市场提供碳选择性检测器（CSD）。 CSD是一种高效液相色谱（HPLC）检测器，使用火焰离子化检测器（FID）和催化反应器对所有有机化合物产生线性响应。关键的创新是催化反应器的新开发和使用，以转化有机分子并去除液相色谱流出物流中的溶剂。FID与气相色谱（GC）系统中普遍存在的FID类似，对转化为甲烷的有机化合物产生通用响应，具有无与伦比的线性范围和稳健性。该设备将克服FID的限制，这些限制阻碍了以前在HPLC中的使用，通过选择性地去除溶剂，将有机化合物氧化为二氧化碳，将二氧化碳还原为甲烷，并使用FID检测产生的甲烷。 由此产生的产品功能，最值得注意的是对碳的普遍反应，将为临床前制药研究人员提供一种工具，可以在筛选过程中量化药物及其副产物，该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查进行评估来支持的搜索.