SBIR Phase II: A carbon selective detector for liquid phase chemical detection of organic molecules

SBIR Phase II：用于有机分子液相化学检测的碳选择性检测器

• 批准号: 1853063
• 负责人: Andrew Jones
• 金额: $ 71.42万
• 依托单位: Activated Research Company
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1853063&HistoricalAwards=false
• 关键词: SBIR; Phase; II; carbon; selective

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the potential to directly and positively impact the speed of chemical analysis leading to cleaner and more advanced products. Technology resulting from the proposed activity will solve several pain points in the chemical analysis industry, including non-linearity, small dynamic range and variable, sometimes negligible, detector response. As a result, the technology will have broad use and lead to improved detection in pharmaceuticals, drug development, fuels, chemicals, renewables, foods, flavors, and academic and industrial research. Uniform response to carbon from flame ionization detection (FID) would be completely disruptive to the painstaking methods of calibration of known compounds and the guesswork associated with the quantification of unknowns. The benefits of this technology are expected to result in immense improvements in the speed and accuracy of high-performance liquid chromatography (HPLC) analysis, thereby leading to better and safer products, with faster development times. Applied to the pharmaceutical and new drug development industry, this technology will have lasting impacts on the health and safety of society due to better and faster analyses available.This SBIR Phase II project aims to deliver a carbon selective detector (CSD) to the global scientific market. The CSD is a high-performance liquid chromatography (HPLC) detector that produces a linear response to all organic compounds using a flame ionization detection (FID) and a catalytic reactor. The key innovation is the novel development and use of a catalytic reactor to transform organic molecules and remove solvent in liquid chromatograph effluent streams. The FID, similar to those ubiquitous in gas chromatography (GC) systems, yields a universal response to organic compounds converted to methane with unparalleled linear range and robustness. The device will overcome limitations of the FID that have prevented previous use in HPLC by selectively removing solvents, oxidizing organic compounds to carbon dioxide, reducing carbon dioxide to methane, and detecting the resulting methane with the FID. The resulting product features, most notably a universal response to carbon, will provide pre-clinical pharmaceutical researchers with a tool that can quantify drugs and their by-products during screening, long before the process has been scaled up for the production of calibration standards.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 第二阶段项目更广泛的影响/商业潜力是有可能直接、积极地影响化学分析的速度，从而产生更清洁、更先进的产品。拟议活动所产生的技术将解决化学分析行业的几个痛点，包括非线性、小动态范围和可变（有时可以忽略不计）的检测器响应。因此，该技术将具有广泛的用途，并改善制药、药物开发、燃料、化学品、可再生能源、食品、香料以及学术和工业研究领域的检测。火焰离子化检测 (FID) 对碳的均匀响应将完全颠覆已知化合物校准的艰苦方法以及与未知物量化相关的猜测。该技术的优势预计将极大提高高效液相色谱 (HPLC) 分析的速度和准确性，从而带来更好、更安全的产品，并缩短开发时间。该技术应用于制药和新药开发行业，由于可以提供更好、更快的分析，将对社会的健康和安全产生持久影响。SBIR 第二阶段项目旨在向全球科学市场提供碳选择性检测器 (CSD)。 CSD 是一种高性能液相色谱 (HPLC) 检测器，使用氢火焰离子化检测 (FID) 和催化反应器对所有有机化合物产生线性响应。关键的创新是催化反应器的新颖开发和使用，以转化有机分子并去除液相色谱流出液中的溶剂。 FID 与气相色谱 (GC) 系统中常见的 FID 类似，可以对转化为甲烷的有机化合物产生通用响应，具有无与伦比的线性范围和稳健性。该设备将通过选择性去除溶剂、将有机化合物氧化为二氧化碳、将二氧化碳还原为甲烷以及用 FID 检测所得甲烷，克服 FID 先前在 HPLC 中使用的局限性。 由此产生的产品功能，最显着的是对碳的普遍响应，将为临床前药物研究人员提供一种工具，可以在筛选过程中量化药物及其副产品，早在该过程扩大用于生产校准标准之前。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。