Dielectric Studies of Proteins

蛋白质的介电研究

• 批准号: 9701453
• 负责人: Lois Pollack
• 金额: $ 5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701453&HistoricalAwards=false
• 关键词: Dielectric; Studies; Proteins

9701453 Pollack This is a Woman Career Advancement Award to study the dielectric properties of proteins. The goal of these experiments is to study the important problems of protein shape (conformation) and protein folding, the process by which a linear chain of amino acids assumes the shape which allows the protein to perform its specific function. Folding intermediates of proteins will be studied with different techniques, such as measurements of the dielectric constant of a protein solution. The dielectric constant is a measure of the distribution of charge within the macromolecule and changes as the protein folds. Membrane proteins will also be studied. %%% This is a Woman Career Advancement Award to study the dielectric properties of proteins. Proteins are large molecules that consist of a long chain of amino acids. The molecule 'folds' itself into a specific shape that dictates its function. The goal of these experiments is to gain insight into the important problems of protein shape (conformation) and protein folding. Different techniques, such as a detailed measurements of the distribution of positive and negative charges in the molecule, can yield new information about the forces that cause the protein to fold in a unique way. Different types of proteins will be studied, including the important class of proteins that cross membranes. ***

9701453波拉克这是一个女性职业进步奖，旨在研究蛋白质的介电性质。这些实验的目的是研究蛋白质形状(构象)和蛋白质折叠的重要问题，即氨基酸的线性链呈现允许蛋白质执行其特定功能的形状的过程。蛋白质的折叠中间体将用不同的技术进行研究，例如测量蛋白质溶液的介电常数。介电常数是大分子内电荷分布的量度，随着蛋白质折叠而变化。膜蛋白也将被研究。这是一项女性职业发展奖，旨在研究蛋白质的介电性质。蛋白质是由一长串氨基酸组成的大分子。这种分子会将自己‘折叠’成特定的形状，从而决定它的功能。这些实验的目的是深入了解蛋白质形状(构象)和蛋白质折叠的重要问题。不同的技术，例如对分子中正负电荷分布的详细测量，可以产生关于导致蛋白质以独特方式折叠的力的新信息。不同类型的蛋白质将被研究，包括一类重要的跨膜蛋白质。***