CAREER: Transition Metal Initiators for the Synthesis of Well-Defined Polypeptides

职业：用于合成明确多肽的过渡金属引发剂

• 批准号: 9701969
• 负责人: Timothy Deming
• 金额: $ 8万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701969&HistoricalAwards=false
• 关键词: CAREER; Transition; Metal; Initiators; Synthesis

Professor Deming's research focuses on the use of transition metal complexes as initiators for the synthesis of well-defined polypeptides. Polymerization of alpha-amino acid N-carboxyanhydrides using various Cu, Ni, Pd and Zn complexes provides a nonbiological alternative for the preparation of polypeptides, including block co-polymers expected to display properties rivaling those of naturally occurring structural proteins. Light scattering, viscometry, and x-ray diffraction, as well as mechanical testing and processing, will permit characterization and evaluation of the materials produced. Professor Deming will introduce a biomaterials curriculum at the undergraduate and graduate levels, presenting core macromolecular courses and covering biopolymer synthesis and the structure, dynamics, and processing of biomaterials. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Professor Timothy J. Deming of the Materials and Chemistry Departments at the University of California, Santa Barbara. Professor Deming's research focuses on the use of transition metal complexes as initiators for the formation of well-defined polypeptides, specifically targeting materials which are expected to mimic naturally occurring structural polypeptides such as spider silk and collagen. These materials are of particular interest because of their excellent physical properties, biocompatability, biodegradability, and potential for biomedical applications. Professor Deming's educational activities are focused on the development of a new curriculum that consists of a core sequence of courses covering the science of large molecules and additional courses focused on biological materials. This training, at both the undergraduate and graduate levels, will be complemented by student involvement in biomaterials research programs, affording a unique opportunity to participate in multidisciplinary research and laying the groundwork for effective future collaborative research efforts.

德明教授的研究重点是过渡金属的使用 复合物作为合成明确定义的多肽的引发剂。 使用各种Cu， Ni、Pd和Zn络合物提供了一种非生物替代物， 多肽的制备，包括预期 显示出与天然结构相媲美的性能 proteins. 光散射，粘度，和x射线衍射，以及 作为机械测试和加工，将允许表征和 评估所生产的材料。 德明教授将介绍一个 本科生和研究生阶段的生物材料课程， 介绍核心大分子课程和生物聚合物合成 以及生物材料的结构、动力学和加工。 有了这个职业奖，合成有机计划支持 蒂莫西·J·德明教授的研究和教育活动 加州大学材料和化学系， 圣巴巴拉。 德明教授的研究重点是利用 过渡金属络合物作为引发剂， 明确定义的多肽，特别是靶向物质， 预期模拟天然存在的结构多肽， 蜘蛛丝和胶原蛋白 这些材料特别令人感兴趣 由于它们优异的物理性能，生物相容性， 生物降解性和生物医学应用的潜力。 教授 德明的教育活动集中在发展一种新的 课程，包括核心课程序列，涵盖 大分子科学和其他课程，重点是生物 材料. 这种培训，在本科和研究生两级， 将通过学生参与生物材料研究来补充 计划，提供一个独特的机会，参与 多学科研究和奠定基础，有效的未来 合作研究的努力。