Development of Multifunctional Polypeptide Amphiphiles as Drug Delivery Vehicles

多功能多肽两亲物作为药物输送载体的开发

• 批准号: 0907453
• 负责人: Timothy Deming
• 金额: $ 44.96万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907453&HistoricalAwards=false
• 关键词: Development; Multifunctional; Polypeptide; Amphiphiles; Drug

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)This award by the Biomaterials program in the Division of Materials Research to University of California Los Angeles is to develop and study multifunctional amphiphilic block copolypeptides that can be assembled into vesicle and emulsion vehicles containing functionality for intracellular drug delivery. The proposed copolypeptide design, synthesis, development and testing, as well as the functionality and versatility inherent in these polypeptides will be used to create multifunctional vehicles with properties suitable for drug delivery applications. The key challenge of this proposal is to design and prepare polypeptide amphiphiles with added functions without adversely affecting other functions or physical features, to obtain true multifunctional vesicle and emulsion carriers. The knowledge gained from these studies will allow fine tuning of carrier properties for downstream specific uses in encapsulation and delivery of drugs. Students trained under this program will be valuable in the industrial job force (both pharmaceutical and materials science areas) since they will learn fundamentals of polymer synthesis using catalysis and self-assembly, cell culture and intracellular trafficking of drug carriers, as well as more applied areas of materials characterization and property evaluation. The PIs will also continue their academic activities in developing curricula and teaching in bioengineering for both graduates and undergraduates, and involve concepts and laboratory methods.The proposed design, synthesis, development and testing of copolypeptides are expected to produce vesicles with enhanced and multifunctional properties for drug delivery systems. These vesicles are expected to have adequate size, shape, good cell uptake and stability, and cargo loading capacity for drug delivery. The design and synthesis of improved drug delivery vehicles expected from these studies are of broad importance for the pharmaceutical industry, and for human health in general. The academic impact of the proposal is in developing curricula and teaching tools for graduate and undergraduate students.

该奖项由2009年美国复苏和再投资法案（公法111-5）资助。该奖项由加州大学洛杉矶分校材料研究部生物材料项目授予，旨在开发和研究多功能两亲性嵌段共聚肽，其可组装成含有细胞内药物递送功能的囊泡和乳液载体。 所提出的共聚肽设计、合成、开发和测试，以及这些多肽中固有的功能性和多功能性将用于创建具有适合于药物递送应用的性质的多功能载体。该方案的关键挑战是设计和制备具有附加功能的多肽两亲物，而不对其他功能或物理特性产生不利影响，以获得真正的多功能囊泡和乳液载体。从这些研究中获得的知识将允许微调载体性质，用于药物的封装和递送中的下游特定用途。在该计划下培训的学生将在工业就业队伍（制药和材料科学领域）中具有价值，因为他们将学习使用催化和自组装，细胞培养和药物载体的细胞内运输的聚合物合成的基础知识，以及材料表征和性能评估的更多应用领域。研究所也将继续他们的学术活动，在开发课程和教学的生物工程的研究生和本科生，涉及概念和实验室的方法。拟议的设计，合成，开发和测试的多肽有望产生囊泡增强和多功能的药物输送系统的性能。 预期这些囊泡具有足够的大小、形状、良好的细胞摄取和稳定性以及用于药物递送的货物装载能力。从这些研究中预期的改进的药物递送载体的设计和合成对于制药工业和一般的人类健康具有广泛的重要性。 该提案的学术影响是为研究生和本科生开发课程和教学工具。