CAREER: 2-Alkylidene Oxetanes: A Versatile Molecular Scaffold for New Molecules and Advanced Materials

职业：2-亚烷基氧杂环丁烷：新分子和先进材料的多功能分子支架

• 批准号: 9702106
• 负责人: Amy Howell
• 金额: $ 28.32万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9702106&HistoricalAwards=false
• 关键词: CAREER; Alkylidene; Oxetanes; Versatile; Molecular

Professor Howell's research focuses on the synthesis of 2-alkylideneoxetanes and their use as potential inhibitors of serine and cysteine proteases as well as precursors for the synthesis of medium-ring carbocyclic compounds and spiroketals. Compounds bearing structural analogy to simple insect pheromones will be prepared using the latter methodology, which is designed to be simple and chemoselective, without extensive use of protecting groups, while proceeding under mild conditions. Approaches to other functionalities through the intermediacy of 2-alkylideneoxetanes will also be explored, as will the polymerization of 2-alkylideneoxetanes, expected to yield polyketones. Professor Howell will seek to facilitate student and faculty interactions with industry in order to achieve three goals: (1) to increase student appreciation of industrial career opportunities, (2) to improve faculty understanding of how to assist students with their job searches, and (3) to foster academic-industrial and industrial-academic collaborations. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Dr. Amy Howell of the Department of Chemistry at the University of Connecticut. Professor Howell examines the chemistry of a class of versatile precursor molecules that, to this point, have received little attention from the synthetic community. These compounds, comparatively small in size but containing a number of reactive groupings of atoms, permit synthetic access to a wide range of important compounds, including molecules anticipated to display unusual biological activity, as well as polymeric materials. Professor Howell's educational activities target the enhancement of student awareness of career opportunities in industry and the development of faculty-industry collaborations through workshops, in-house courses taught by industrial chemists, and internships in academic and industrial laboratories.

豪厄尔教授的研究重点是合成 2-亚烷基氧杂环丁烷及其作为丝氨酸和丝氨酸蛋白酶的潜在抑制剂的用途 半胱氨酸蛋白酶以及用于合成中环的前体 碳环化合物和螺缩酮。 具有结构的化合物 类似于简单的昆虫信息素将使用后者制备 方法，其设计简单且具有化学选择性， 广泛使用保护基团，同时在温和的 条件 通过中介实现其他功能的方法 的2-亚烷基氧杂环丁烷也将探讨，因为将聚合 2-亚烷基氧杂环丁烷，预期产生聚酮。 豪厄尔教授 将寻求促进学生和教师与行业的互动， 为了达到三个目标：（1）提高学生的欣赏能力 工业职业机会，（2）提高教师的理解 如何帮助学生找工作，（3）培养 学术与工业和工业与学术的合作。 有了这个职业奖，合成有机计划支持 研究和教育活动的艾米豪厄尔博士的部门 康涅狄格大学的化学教授 豪厄尔教授研究了 一类多功能前体分子的化学性质， 这一点，几乎没有受到合成社区的关注。 这些化合物体积相对较小，但含有大量的 原子的反应性基团，允许合成获得广泛的 重要的化合物，包括预期显示出不寻常的分子， 生物活性，以及聚合物材料。 豪厄尔教授 教育活动的目的是提高学生对 在行业的职业机会和学院产业的发展 通过研讨会，由工业界教授的内部课程 化学家，并在学术和工业实验室实习。