CRIF: Upgrade of a 400 MHz NMR Spectrometer

凭借化学研究仪器和设施：多用户计划（CRIF：MU）的这一奖项，Steven Suib教授和康涅狄格大学的同事Christian Brueckner，Amy豪厄尔，Nicholas Leadbeater和Mark Peczuh将获得一个控制台和探头，以升级400 MHz NMR光谱仪。该奖项将加强各级的研究培训和教育，特别是在以下研究领域：（a）通过催化剂、表面、陶瓷、粘合剂和其他材料的分子设计进行合成，（B）合成和开发具有α-不饱和度的应变杂环，包括β-内酯，（c）合成和研究吡咯修饰的卟啉，（d）分子合成及其与天然产物相比的生物学特性的表征，（e）开发有机化学的新合成方法，特别是使用微波加热的方法，（f）研究聚合物材料中的共价和非共价分子相互作用，其导致纳米至微米范围内的自组装结构，（g）通过使用细胞功能的小分子效应物来研究细胞信号传导和细胞迁移，（h）合成定义明确的聚合物，通常是两亲性嵌段共聚物，用于自组装;（i）利用分子光笼理解金属离子在细胞内和细胞间信号传导中的作用，以及硝基苄基和偶氮苯发色团的光化学。核磁共振（NMR）光谱是化学家用于阐明分子结构的最有力的工具之一。它用于识别未知物质，跟踪化学反应的进展，表征分子内原子的特定排列，以及研究固体和溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的进行前沿化学相关的研究和培养学生的现代研究技术。该光谱仪将用于本科生和研究生的研究项目和实验室课程。

With this award from the Chemistry Research Instrumentation and Facilities: Multi-User program (CRIF:MU), Professor Steven Suib and colleagues Christian Brueckner, Amy Howell, Nicholas Leadbeater and Mark Peczuh from the University of Connecticut will acquire a console and probe to upgrade a 400 MHz NMR spectrometer. This award will enhance research training and education at all levels, especially in areas of study such as (a) synthesis by molecular design of catalysts, surfaces, ceramics, adhesives and other materials, (b) synthesis and exploitation of strained heterocycles with alpha-unsaturation, including beta-lactones, (c) synthesis and study of pyrrole-modified porphyrins, (d) synthesis of molecules and the characterization of their biological properties in comparison to natural products, (e) development of new synthetic methodology for organic chemistry, particularly that using microwave heating, (f) investigation of covalent and non-covalent molecular interactions in polymeric materials that result in self-assembled structures in the nanometer to micrometer regime, (g) study cell signaling and cell migration by using small molecule effectors of cellular function, (h) synthesis of well-defined polymers, normally amphiphilic block copolymers, for applications in self-assembly, and (i) understanding the role metal ions play in intracellular and intercellular signaling using molecular photocages, and the photochemistry of nitrobenzyl and azobenzene chromophores.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to follow the progress of chemical reactions, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solids and in solution. Access to state-of-the-art NMR spectrometers is essential to carry out frontier chemistry related research and to train students in modern research techniques. The spectrometer will be used by undergraduate and graduate students in research projects and in laboratory courses.