Unusual Oxetanes as New Scaffolds in Organic Synthesis

康涅狄格大学化学系的Amy Howell教授在有机和大分子化学项目的支持下，对2,3-二甲基乙氧基烷和1,5-二氧基螺[3.2]己烷的合成和反应性进行了研究。将研究2,3-二甲基乙氧烷转化为高功能化酮和烯醇，这些关键中间体将用于合成rubifolide，呋喃膜和烯二炔的新方法。1,5-二恶斯匹罗[3.2]己烷将被用作制备核苷类似物的中间体。在有机和大分子项目的支持下，Howell教授正在开发新的方法，通过这种方法，某些高度紧张的有机化合物可以进一步转化为核苷类似物和其他天然产物。核苷类似物可能作为新的化疗药物有潜在的应用。

Professor Amy Howell in the Department of Chemistry at the University of Connecticut is supported by the Organic and Macromolecular Chemistry Program for her research into the synthesis and reactivity of 2,3-dimethylenoxetanes and 1,5-dioxaspiro[3.2]hexanes. The conversion of 2,3-dimethylenoxetanes into highly functionalized ketones and enynols will be studied and these key intermediates will be used in syntheses of rubifolide, a furan cembrane, and a new approach to enediynes. The 1,5-dioxaspiro[3.2]hexanes will be utilized as intermediates in the preparation of nucleoside analogs. With the support of the Organic and Macromolecular Program, Professor Howell is developing novel methods by which certain highly strained organic compounds can be further converted to nucleoside analogs and other natural products. The nucleoside analogs may have potential applications as new chemotherapeutic agents.