Unusual Oxetanes as New Scaffolds in Organic Synthesis

不寻常的氧杂环丁烷作为有机合成中的新支架

• 批准号: 0111522
• 负责人: Amy Howell
• 金额: $ 28.8万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111522&HistoricalAwards=false
• 关键词: Unusual; Oxetanes; New; Scaffolds; Organic

Professor Amy Howell in the Department of Chemistry at the University of Connecticut is supported by the Organic and Macromolecular Chemistry Program for her research into the synthesis and reactivity of 2,3-dimethylenoxetanes and 1,5-dioxaspiro[3.2]hexanes. The conversion of 2,3-dimethylenoxetanes into highly functionalized ketones and enynols will be studied and these key intermediates will be used in syntheses of rubifolide, a furan cembrane, and a new approach to enediynes. The 1,5-dioxaspiro[3.2]hexanes will be utilized as intermediates in the preparation of nucleoside analogs. With the support of the Organic and Macromolecular Program, Professor Howell is developing novel methods by which certain highly strained organic compounds can be further converted to nucleoside analogs and other natural products. The nucleoside analogs may have potential applications as new chemotherapeutic agents.

康涅狄格大学化学系的Amy豪厄尔教授因其对2，3-二甲基氧杂环丁烷和1，5-二氧杂螺[3.2]己烷的合成和反应性的研究而获得有机和大分子化学计划的支持。 研究了2，3-二甲基烯氧杂环丁烷转化为高官能化酮和烯炔醇的反应，这些关键中间体将用于合成呋喃环膜--红酮内酯，并为合成烯二炔开辟了新的途径。 1，5-二氧杂螺[3.2]己烷将用作制备核苷类似物的中间体。 在有机和大分子项目的支持下，豪厄尔教授正在开发新的方法，通过这些方法，某些高度紧张的有机化合物可以进一步转化为核苷类似物和其他天然产物。 核苷类似物作为新的化疗药物具有潜在的应用前景。