Structural biology of plant potyvirus and cytomegalovirus effector proteins (A03)

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The structural determinants of plant potyvirus and metazoan cytomegalovirus (CMV) infection mechanisms will be characterized in A3. Higher oligomeric complexes formed by the CMV proteins IE1 and pUL50-pUL53 as well as plant potyvirus capsid proteins will be produced and crystallized. These crystallographic studies will be paralleled by fragment screening by X-ray crystallography efforts with available crystals of IE1 and pUL50-pUL53, crosslinking experiments and mutagenesis inquiries as well as in-depth studies by our collaborators from projects A2, A7, B3, C2 and C3.