International Research Fellow Awards: Sequence-Specific Binding of Peptide Nucleic Acids to Folded RNA Structures

9703804阿米蒂奇国际研究员奖计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该项目的奖项提供了联合研究的机会，并提供了使用国外独特或互补的设施、专业知识和实验条件的机会。该奖项将支持布鲁斯·A·阿米蒂奇博士与彼得·E·尼尔森博士在丹麦哥本哈根帕纳姆研究所进行为期三个月的博士后研究访问。阿米蒂奇博士将研究肽核酸(PNA)低聚物与RNA分子的相互作用。他的主要假设是，PNA与合成核酶RNA的相互作用是否会抑制核酶的自我剪接。这项工作将增加对PNA与折叠RNA分子相互作用的理解，这些分子是PNA作为反义治疗和诊断试剂发展的重要组成部分。尼尔森博士是PNA的发明者之一，因此在这些分子的合成和应用方面最有经验。此外，尼尔森的同事亨里克·尼尔森博士还将贡献核糖核酸和核酶方面的专业知识。阿米蒂奇博士凭借他在苯醌化学和光化学方面的经验完成了这项合作。***

9703804 Armitage The International Research Fellow Awards Program enables U.S. scientists and engineers to conduct three to twentyfour months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a three-month postdoctoral research visit by Dr. Bruce A. Armitage to work with Dr. Peter E. Nielsen at the Panum Institute in Copenhagen, Denmark. Dr. Armitage will study the interaction of peptide nucleic acid (PNA) oligomers with RNA molecules. His major hypothesis is whether the interaction of PNA with synthetic ribozyme RNA will inhibit ribozyme self-splicing. This work will give increased understanding into the interaction of PNA with folded RNA molecules, which are essential components in the development of PNA as an antisense therapeutic and diagnostic agent. Dr. Nielsen is one of the inventors of PNA and therefore is most experienced in the synthesis and application of these molecules. In addition, Nielsen's colleague, Dr. Henrik Nielsen will contribute expertise in RNA and ribozymes. Dr. Armitage completes the collaboration with his experience in quinone chemistry and photochemistry. ***