Collaborative Research: Directed Charge Transfer in Metal Containing Peptide Nucleic Acid Assemblies

合作研究：含金属肽核酸组装体中的定向电荷转移

• 批准号: 1059037
• 负责人: Bruce Armitage
• 金额: $ 39万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1059037&HistoricalAwards=false
• 关键词: Collaborative; Research; Directed; Charge; Transfer

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Catalina Achim of Carnegie Mellon University, David Waldeck of University of Pittsburgh, and David Beratan of Duke University will develop hybrid inorganic-nucleic acid structures and study charge transfer through these structures with the goal to direct and control charge flow on length scales up to tens of nanometers. Peptide nucleic acid (PNA) building blocks that contain electroactive units will be used, together with complementary nucleic acids (DNA or PNA) as a template for the building blocks, to self-assemble and form preprogrammed electroactive assemblies. The key feature of the proposed research is the general and modular approach to incorporate inorganic or organic charge transfer components at predefined spatial locations in a nucleic acid-based structural scaffold. The team of researchers with complementary expertise (synthesis, characterization, and theory) will collaborate to define the synthetic methodologies, to develop the predictive models, and to quantify the structure and the function of these novel electroactive, supramolecular structures. The broader impacts of this collaborative research program originate from: (1) the creation of new paradigms for charge transfer, (2) the creation of new pedagogical tools for science education that make use of cyber-infrastructure, and (3) outreach activities that enhance diversity in the STEM workforce. This work will enhance our fundamental understanding of charge transfer in nano-size, supramolecular structures that mimic similar-size structures present in biological systems. Ultimately such work could lead to a general approach for integrating electronic platforms with biological systems.

在这个由化学部高分子、超分子和纳米化学项目资助的项目中，卡内基梅隆大学的 Catalina Achim、匹兹堡大学的 David Waldeck 和杜克大学的 David Beratan 将开发混合无机核酸结构并研究通过这些结构的电荷转移，目标是在长达数十纳米的长度尺度上引导和控制电荷流。包含电活性单元的肽核酸（PNA）构建块将与作为构建块模板的互补核酸（DNA或PNA）一起使用，以自组装并形成预编程的电活性组件。该研究的主要特点是采用通用和模块化的方法，将无机或有机电荷转移成分合并到基于核酸的结构支架中的预定空间位置。具有互补专业知识（合成、表征和理论）的研究人员团队将合作定义合成方法，开发预测模型，并量化这些新型电活性超分子结构的结构和功能。该合作研究计划的更广泛影响源于：(1) 创建电荷转移新范式，(2) 创建利用网络基础设施的新科学教育教学工具，以及 (3) 增强 STEM 劳动力多样性的外展活动。这项工作将增强我们对纳米级超分子结构中电荷转移的基本理解，这些结构模仿生物系统中存在的类似尺寸的结构。 最终，此类工作可能会产生一种将电子平台与生物系统集成的通用方法。