Regulation of nuclear egress of human cytomegalovirus through a multifunctional viral-cellular protein complex (C03)

通过多功能病毒-细胞蛋白复合物调节人巨细胞病毒的核排出（C03）

• 批准号: 114257065
• 金额: --
• 依托单位: Virologisches Institut - Klinische und Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/114257065?language=en
• 关键词: Regulation; nuclear; egress; human; cytomegalovirus

The C3 work program addresses four topics: (i) the mechanistic characterization of HCMV-specific core NEC heterodimerization, (ii) the question of conservation of this essential NEC scaffolding principle among herpesviruses, (iii) a detailed analysis of the various regulatory functions recruited to the multimeric NEC and, (iv) an exploitation of the NEC as a putative cross-spanning antiherpesviral drug target. Thus, our project will provide new information on the NEC-specific structure-function relationship focusing on its multifaceted mode of virus-host interaction.

C3工作计划涉及四个主题：（i）HCMV特异性核心NEC异源二聚化的机制表征，（ii）疱疹病毒中这种基本NEC支架原理的保守性问题，（iii）对多聚体NEC招募的各种调控功能的详细分析，以及（iv）NEC作为假定的跨跨抗疱疹病毒药物靶标的开发。因此，我们的项目将提供新的信息，对NEC的具体结构与功能的关系，侧重于其多方面的病毒-宿主相互作用的模式。