Regulation of nuclear egress of human cytomegalovirus through a multifunctional viral-cellular protein complex (C03)

C3工作计划涉及四个主题：(i) hcmv特异性核心NEC异二聚化的机制特征，（ii）疱疹病毒中NEC基本支架原理的保护问题，（iii）多聚NEC募集的各种调节功能的详细分析，（iv） NEC作为推定的跨跨抗疱疹病毒药物靶点的开发。因此，我们的项目将提供有关nec特异性结构-功能关系的新信息，重点关注其病毒-宿主相互作用的多方面模式。

The C3 work program addresses four topics: (i) the mechanistic characterization of HCMV-specific core NEC heterodimerization, (ii) the question of conservation of this essential NEC scaffolding principle among herpesviruses, (iii) a detailed analysis of the various regulatory functions recruited to the multimeric NEC and, (iv) an exploitation of the NEC as a putative cross-spanning antiherpesviral drug target. Thus, our project will provide new information on the NEC-specific structure-function relationship focusing on its multifaceted mode of virus-host interaction.