New Avenues for the Intramolecular Diyl Trapping Reaction

本研究的重点将是利用双自由基化学发展新的合成方法。本论文主要研究了三亚甲基甲烷（TMM）二烃基的原子转移化学、TMM二自由基的（4+3）-环加成反应以及乙烯基环丙基取代的TMM二烃基的断裂/环化反应。选择了适当的合成目标来展示方法。有了这个更新奖，合成有机计划是支持R博士的研究工作。位于圣巴巴拉的加州大学化学系的Danial Little说。利特尔教授将把他的工作重点放在开发涉及双自由基的三个过程上。原子转移反应，与1，3-二烯的反应和断裂环化反应都将被探索，以开发新的方法来构建感兴趣的天然产物。

The focus of this research will be the development of new synthetic methodology using diradical chemistry. Atom transfer chemistry of trimethylenemethane (TMM) diyls, (4+3) - cycloadditons to TMM diradicals and fragmentation/cyclization of vinylcyclopropyl substituted TMM diyls will be probed. Appropriate synthetic targets have been chosen to showcase the methodology. With this renewal award, the Synthetic Organic Program is supporting the research efforts of Dr. R. Danial Little of the Department of Chemistry at the University of California, Santa Barbara. Professor Little will focus his work on developing three processes involving diradicals. Atom transfer reactions, reactions with 1,3-dienes and fragmentation-cyclization reactions will all be explored in order to develop new methodology for the construction of interesting natural products.