Lanthanide Ion Luminescence, Chelate and Supramolecular Chemistry Relevant to Clinical Agent, Optical Device, and Chemosensor Applications

无机化学、生物无机化学和金属有机化学项目的这笔拨款支持威廉·鲁教授的工作。宾夕法尼亚州立大学的霍罗克。这项研究的目的是：1)回答有关稀土络合物形成的基本问题，这对用磁共振技术成像内部生物结构具有重要意义；2)发展一种新的水溶液中稀土离子的超分子化学；3)利用最近发现的近红外光敏发射现象来开发化学传感器。为了更好地了解目前用于影响质子弛豫时间的成像试剂，并开发旨在改进这些试剂的新化学，将对稀土络合物的化学和发光进行研究。一种新型的具有稳定的低能量(近红外)发射的络合物将被探索用于化学传感器和其他应用。将在水中制备由稀土亚基组成的新的大分子结构。

This grant in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor William DeW. Horrocks of the Pennsylvania State University. The research is aimed toward: 1) answering fundamental question regarding the formation of lanthanide chelate complexes, which are important in imaging internal biological structures by magnetic resonance techniques, 2) developing a new supramolecular chemistry of lanthanide ions in aqueous solution, and 3) exploiting a recently discovered photosensitized emission phenomenon in the near infrared to develop chemosensors. The chemistry and luminescence of lanthanide complexes will be investigated in order to better understand present agents used to affect proton relaxation times for imaging purposes and to develop new chemistry aimed toward improving these agents. A new type of complex exhibiting a stable low energy (near infrared) emission will be explored for chemosensor and other applications. New large molecular structures composed of lanthanide subunits will be prepared in water.