Laser-Excited Lanthanide Ion Luminescence in Chemistry and Biophysics

化学和生物物理学中的激光激发镧系离子发光

• 批准号: 9123801
• 负责人: William Horrocks
• 金额: $ 32.6万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9123801&HistoricalAwards=false
• 关键词: Laser; Excited; Lanthanide; Ion; Luminescence

This project, in the Inorganic, Bioinorganic and Organometallic Chemistry Program, focusses on the use of lanthanide ion luminescence to investigate diffusion-enhanced energy transfer between lanthanide energy donors and inorganic acceptors. The objective is to develop an understanding of resonant exchange energy transfer previously shown to dominate these systems and of chiral discrimination in the energy transfer between chiral lanthanide and chiral inorganic ions. Also to be examined are lanthanide complexes as intercalation agents for probes of double-helical DNA and as targeted MRI agents, further studies of the photophysics of sensitized luminescence for immunoassay analytical applications, and characterization of siderophore and model siderophore complexes of lanthanide ions. Molecular mechanics/dynamics calculations will be used to direct the design of certain reagents, particularly in chiral recognition and DNA intercalation. %%% This project is concerned with the use of the special luminescence characteristics of lanthanide ions that result from laser irradiation to examine a variety of chemical events and to develop improved methods that may have potential for the study of metal ion-protein and metal ion-DNA interactions, and ultimately for clinical analyses.

这个项目，在无机，生物无机和有机 化学计划，侧重于使用镧系元素离子 研究扩散增强的能量转移 镧系元素能量供体和无机受体之间。的 目的是了解共振交换 先前显示的能量转移在这些系统中占主导地位， 手性物质之间能量转移的手性鉴别 镧系元素和手性无机离子。 还将审查的是 镧系元素络合物作为探针的嵌入剂 双螺旋DNA和作为靶向MRI剂，进一步的研究 致敏发光免疫分析的电子物理学 铁载体的分析应用和表征 和镧系元素离子的模型铁载体络合物。 分子 力学/动力学计算将用于指导 某些试剂的设计，特别是在手性识别中 和DNA嵌入。 %%% 本项目涉及使用特殊的 镧系元素离子的发光特性， 从激光照射到检测各种化学事件 并开发可能具有潜力的改进方法， 研究金属离子-蛋白质和金属离子-DNA相互作用， 最终用于临床分析。