Laser-Excited Lanthanide Ion Luminescence in Chemistry and Biophysics

在无机化学、生物无机化学和金属有机化学计划中，该项目主要利用稀土离子发光来研究稀土能量供体和无机受体之间的扩散增强能量传递。其目的是加深对以前证明主导这些体系的共振交换能量转移的理解，以及对手性稀土和手性无机离子之间能量转移的手性区分的理解。此外，还将研究作为双螺旋DNA探针的插层剂和靶向MRI试剂的稀土配合物，用于免疫分析应用的敏化发光的光物理的进一步研究，以及稀土离子的铁载体和模型铁载体配合物的表征。分子力学/动力学计算将被用来指导某些试剂的设计，特别是在手性识别和DNA嵌入方面。这个项目涉及利用激光照射产生的稀土离子的特殊发光特性来研究各种化学事件，并开发可能有潜力研究金属离子-蛋白质和金属离子-DNA相互作用的改进方法，并最终用于临床分析。

This project, in the Inorganic, Bioinorganic and Organometallic Chemistry Program, focusses on the use of lanthanide ion luminescence to investigate diffusion-enhanced energy transfer between lanthanide energy donors and inorganic acceptors. The objective is to develop an understanding of resonant exchange energy transfer previously shown to dominate these systems and of chiral discrimination in the energy transfer between chiral lanthanide and chiral inorganic ions. Also to be examined are lanthanide complexes as intercalation agents for probes of double-helical DNA and as targeted MRI agents, further studies of the photophysics of sensitized luminescence for immunoassay analytical applications, and characterization of siderophore and model siderophore complexes of lanthanide ions. Molecular mechanics/dynamics calculations will be used to direct the design of certain reagents, particularly in chiral recognition and DNA intercalation. %%% This project is concerned with the use of the special luminescence characteristics of lanthanide ions that result from laser irradiation to examine a variety of chemical events and to develop improved methods that may have potential for the study of metal ion-protein and metal ion-DNA interactions, and ultimately for clinical analyses.