Mechanisms of Iron-Ligand Exchange Reactions and the Influence of Ionophore Hosts and Micelles in the Second- Sphere

铁-配体交换反应的机制以及第二球体离子载体和胶束的影响

• 批准号: 9709105
• 负责人: Alvin Crumbliss
• 金额: $ 33.5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9709105&HistoricalAwards=false
• 关键词: Mechanisms; Iron; Ligand; Exchange; Reactions

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program with a contribution from the Mathematics and Physical Sciences Office of Multidisciplinary Activities for instrumentation supports research in the laboratory of Alvin L. Crumbliss in the Department of Chemistry at Duke University. The proposed work will explore the effects of second sphere coordination on the chemistry (transport properties, reduction potentials and substitution kinetics) of iron siderophore complexes. Siderophore complexes are responsible for transporting iron from the environment into bacterial cells. Through a collaborative effort, pendant ligands would be attached onto a number of siderophores or synthetic hydroxamic acids in order to study specific second-sphere effects. Complexes will also be enclosed into micelles in order to mimic the effect of cell membranes. The chemistry of iron siderophores provides insight into how iron is transported into cells in the environment. This research explores how interactions through ligands that are not directly attached to the iron affect the uptake, release and transport across cell membranes of this essential element in all living systems.

该奖项在无机，生物无机和有机 化学计划与数学和物理的贡献 仪器多学科活动科学办公室 支持了Alvin L.实验室的研究。Crumbliss在 杜克大学化学系。 拟议的工作将 探讨第二配位圈对化学的影响 （传输特性、还原电位和取代动力学） 铁载体复合物。 铁载体复合物负责 将铁从环境中运输到细菌细胞中。 通过 通过协作，悬垂配体将被连接到许多 铁载体或合成异羟肟酸，以研究特定的 第二层效应。 配合物也将被封闭到胶束中， 以模拟细胞膜的作用。 铁铁载体的化学性质提供了铁是如何被 被运输到环境中的细胞中。 这项研究探讨了如何 通过不直接连接到铁的配体的相互作用 影响这种物质的吸收、释放和跨细胞膜转运 所有生命系统中的基本元素。