RUI:CAS: New Ligand Platforms for the Synthesis and Study of High-Spin Iron(I) Dinitrogen Complexes
RUI:CAS:用于合成和研究高自旋铁(I)二氮配合物的新配体平台
基本信息
- 批准号:1954883
- 负责人:
- 金额:$ 22.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Paul J. Fischer in the Department of Chemistry at Macalester College to develop new iron compounds that bind nitrogen gas. Comprising nearly 80% of air, nitrogen gas is inert toward most chemical reactions. Because of this inertness, nitrogen resists incorporation by reductive chemistry into useful nitrogen-rich components of fertilizers and pharmaceuticals. The goal of this project is to discover new approaches to enhance the reactivity of nitrogen. The specific concept involves converting nitrogen gas into compounds containing iron. Indeed, Fischer’s research program has identified a family of organic compounds that bind iron, allowing it to activate gaseous nitrogen. The research is being conducted by Professor Fischer and undergraduate students in an environment that fosters diversity by including women and members of groups underrepresented in chemistry. Through this research, the project is providing hands-on training to participants in advanced organic and inorganic chemistry. Student coworkers are prepared for pursuing STEM (science, technology, engineering, and mathematics) careers in academia, industry, or federal laboratories.This project contributes to the "grand challenge" of the development of catalytic/stoichiometric reactions for the manipulation of iron-dinitrogen complexes in a quest to uncover new pathways for N2 functionalization. A family of terminal high-spin iron(I) dinitrogen complexes are targeted. These new complexes allow systematic study of variables affecting the iron-bound dinitrogen ligands in trigonally coordinated and modulated weak ligand fields. A variety of supporting ligands will be examined, with particular emphasis on the pyrazolate motif. Particular attention is paid to the reduction potentials of the new complexes. This project will also explore the reactivity of terminal iron(I) dinitrogen complexes with respect to dinitrogen substitution with diamagnetic and paramagnetic ligands. Additions of organic radicals to terminal dinitrogen ligands will be investigated as one pathway to organic nitrogen products. The functionalization of an iron-coordinated terminal dinitrogen ligand by radical addition would represent an exciting new pathway for iron-mediated dinitrogen reactivity. The research program draws participants from a diverse campus community, providing them with practical, hands-on training in laboratory operations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
有了这个奖项,NSF化学部的化学合成计划正在支持Macalester学院化学系Paul J. Fischer教授的研究,以开发新的结合氮气的铁化合物。氮气几乎占空气的80%,对大多数化学反应是惰性的。由于这种惰性,氮抵抗通过还原化学结合到肥料和药物的有用的富氮组分中。该项目的目标是发现新的方法来提高氮的反应性。 具体概念涉及将氮气转化为含铁化合物。事实上,费舍尔的研究计划已经确定了一个有机化合物的家庭,结合铁,使其能够激活气态氮。这项研究由Fischer教授和本科生在一个通过纳入女性和化学领域代表性不足的群体成员来促进多样性的环境中进行。通过这项研究,该项目正在为高级有机和无机化学的参与者提供实践培训。学生同事为在学术界,工业界或联邦实验室从事STEM(科学,技术,工程和数学)职业做好准备。该项目有助于开发用于操纵铁-二氮络合物的催化/化学计量反应的“重大挑战”,以探索N2功能化的新途径。一个家庭的终端高自旋铁(I)二氮配合物的目标。 这些新的配合物允许系统的变量影响铁结合的二氮配体在三角协调和调制弱配体领域的研究。各种支持配体将被检查,特别强调吡唑基序。特别注意的是支付给新的配合物的还原电位。本项目还将探讨末端铁(I)二氮配合物与抗磁性和顺磁性配体的二氮取代反应性。将有机自由基加成到末端二氮配体作为有机氮产物的一种途径进行研究。通过自由基加成将铁配位的末端二氮配体官能化将代表铁介导的二氮反应性的令人兴奋的新途径。该研究项目吸引了来自多元化校园社区的参与者,为他们提供实验室操作方面的实用动手培训。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Exploring opportunities for tuning phenyltris(pyrazol-1-yl)borate donation by varying the extent of phenyl substituent fluorination
- DOI:10.1039/d3dt00735a
- 发表时间:2023-04-04
- 期刊:
- 影响因子:4
- 作者:Fischer, Paul J.;Roe, Charley B.;Young Jr, Victor G.
- 通讯作者:Young Jr, Victor G.
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Paul Fischer其他文献
A Time-Relaxation Reduced Order Model for the Turbulent Channel Flow
湍流通道流的时间松弛降阶模型
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Ping;Paul Fischer;T. Iliescu - 通讯作者:
T. Iliescu
Modification of Kv4.2 Channel Complexes by the Diphenylurea Compound NS5806
- DOI:
10.1016/j.bpj.2011.11.2912 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Katrin Witzel;Regina Westermeier;Paul Fischer;Robert Bähring - 通讯作者:
Robert Bähring
Plasmacytoid dendritic cell interaction with HIV-infected T cells: Live cell nibbling vs cell–cell fusion
- DOI:
10.1016/j.cyto.2009.07.214 - 发表时间:
2009-10-01 - 期刊:
- 影响因子:
- 作者:
Evan S. Jacobs;Thaddeus C. George;Sukhwinder Singh;Richard Wnek;Paul Fischer;Shila K. Nordone;Gregg A. Dean;Patricia Fitzgerald-Bocarsly - 通讯作者:
Patricia Fitzgerald-Bocarsly
Post-release survival and prolonged sublethal effects of capture and barotrauma on deep-dwelling rockfishes (genus Sebastes): implications for fish management and conservation
捕获和气压伤对深海石斑鱼(Sebastes 属)的释放后生存和长期亚致死影响:对鱼类管理和保护的影响
- DOI:
10.1093/icesjms/fsab188 - 发表时间:
2021 - 期刊:
- 影响因子:3.3
- 作者:
N. Wegner;Elan J. Portner;Drew T. Nguyen;L. Bellquist;A. Nosal;A. Pribyl;K. Stierhoff;Paul Fischer;Ken Franke;R. Vetter;P. Hastings;B. Semmens;J. Hyde - 通讯作者:
J. Hyde
Rhodopsin activation involves an ensemble of conformational substates
- DOI:
10.1016/j.bpj.2021.11.2308 - 发表时间:
2022-02-11 - 期刊:
- 影响因子:
- 作者:
Andrey V. Struts;Eglof Ritter;Paul Fischer;Blake Mertz;Franz Bartl;Michael F. Brown - 通讯作者:
Michael F. Brown
Paul Fischer的其他文献
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{{ truncateString('Paul Fischer', 18)}}的其他基金
RUI: An Examination of the Utility of Tris(phosphino)borates as Supporting Ligands for Rhenium(I) Dihapto-Arene Complexes
RUI:三(膦基)硼酸盐作为铼(I)二羟基芳烃配合物支持配体的实用性检验
- 批准号:
1464515 - 财政年份:2015
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
RUI: Synthesis and Reactivity of Coordinatively Unsaturated Zwitterionic Half-Sandwich Group VIII Metal Complexes
RUI:配位不饱和两性离子半夹心第VIII族金属配合物的合成和反应活性
- 批准号:
1011800 - 财政年份:2010
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
MRI: Acquisition of a 400 MHz NMR Spectrometer to Facilitate Research and Undergraduate Research Training
MRI:购买 400 MHz NMR 波谱仪以促进研究和本科生研究培训
- 批准号:
1039655 - 财政年份:2010
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
CMG Collaborative Research: Ocean Modeling by Bridging Primitive and Boussinesq Equations
CMG 合作研究:通过连接原始方程和 Boussinesq 方程进行海洋建模
- 批准号:
1025359 - 财政年份:2010
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
CMG Collaborative Research: A New Modeling Framework for Nonhydrostatic Simulations of Small-Scale Oceanic Processes
CMG 协作研究:小规模海洋过程非静水力模拟的新建模框架
- 批准号:
0620541 - 财政年份:2006
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
Collaborative Research: Three-Dimensional Numerical Investigation of Density Currents
合作研究:密度流的三维数值研究
- 批准号:
0209304 - 财政年份:2002
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
Parallel Algorithms for General Geometry Navier-Stokes Calculations
一般几何纳维-斯托克斯计算的并行算法
- 批准号:
9405403 - 财政年份:1994
- 资助金额:
$ 22.46万 - 项目类别:
Continuing Grant
Parallel Spectral Element Methods for Viscous Flow Problems in General Domains
一般域粘性流问题的并行谱元方法
- 批准号:
9107674 - 财政年份:1991
- 资助金额:
$ 22.46万 - 项目类别:
Standard Grant
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