Upgrade of the UW Chemistry Department NMR Facility

该奖项由化学研究仪器和设施 （CRIF）计划和主要研究仪器（MRI）计划将 协助华盛顿大学化学系 购买500 MHz NMR光谱仪。该设备将增强 在一些领域的研究，包括过渡中的交换耦合 螺旋/卷曲转变，冷诱导螺旋解折叠; 还原消除反应的能量学和机理;序列 识别域折叠的决定因素;局部 DNA中特殊基团的角运动.蛋白质的测定 结构和动力学;以及 受损的DNA 核磁共振（NMR）光谱是最强大的工具， 化学家用来阐明分子结构的仪器。 它用于识别未知物质，表征特定物质， 分子内原子的排列，并研究 溶液中分子间的相互作用获得最新技术 核磁共振谱是化学家进行前沿研究的基础 research.这些NMR研究的结果在以下领域是有用的， 如聚合物、催化剂和生物学。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Major Research Instrumentation (MRI) Program will assist the Department of Chemistry at University of Washington in the purchase of a 500 MHz NMR spectrometer. This equipment will enhance research in a number of areas including exchange coupling in transition metal polyhydrides; helix/coil transitions, cold-induced helix unfolding; energetics and mechanisms of reductive elimination reactions; sequence determinants of the folding of recognition domains; dynamics of local angular motions of specific groups in DNA; determination of protein structure and dynamics; and structure elucidation for lesion sites in damaged DNA. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.