Purchase of a Quadrupole Ion Trap Mass Spectrometer

购买四极杆离子阱质谱仪

• 批准号: 9807748
• 负责人: Paul Hopkins
• 金额: $ 16.92万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9807748&HistoricalAwards=false
• 关键词: Purchase; Quadrupole; Ion; Trap; Mass

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the University of Washington to acquire a quadrupole ion trap mass spectrometer equipped with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces, which will be interfaced to a liquid chromatograph. This equipment will enhance research in a number of projects involving highly sensitive ionization of involatile polar compounds, peptides, proteins, DNA conjugates, organometallic complexes, negative ion detection, and multi-stage tandem mass spectrometry capabilities at unit mass resolution for singly-charged ions and sub-unit mass resolution for multiply-charged species. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

化学研究仪器和设施(CRIF)计划的这一奖项将帮助华盛顿大学化学系获得配备有电喷雾电离(ESI)和大气压化学电离(APCI)接口的四极离子陷阱质谱仪，该质谱仪将连接到液色仪。该设备将加强一些项目的研究，这些项目涉及非极性化合物、多肽、蛋白质、DNA偶联物、有机金属络合物的高灵敏电离、负离子检测，以及单电荷离子的单位质量分辨率和多电荷物种的亚单位质量分辨率的多级串联质谱学能力。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。