Purchase of a Quadrupole Ion Trap Mass Spectrometer

这份来自化学研究仪器和设施（CRIF）项目的合同将帮助华盛顿大学化学系获得一台配备电喷雾电离（ESI）和大气压化学电离（APCI）接口的四极离子阱质谱仪，该质谱仪将与液相色谱仪连接。该设备将加强对一些项目的研究，包括高灵敏度电离的难折叠极性化合物、肽、蛋白质、DNA偶联物、有机金属配合物、负离子检测，以及单位质量分辨率的单电荷离子和亚单位质量分辨率的多电荷物质的多级串联质谱分析能力。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。电喷雾电离结合高分辨率提供了质谱分析的最新技术。它为化学家提供了表征化合物的最有力的工具之一。在质谱法中获得这种能力对于化学许多领域的前沿研究的进行是必不可少的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the University of Washington to acquire a quadrupole ion trap mass spectrometer equipped with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces, which will be interfaced to a liquid chromatograph. This equipment will enhance research in a number of projects involving highly sensitive ionization of involatile polar compounds, peptides, proteins, DNA conjugates, organometallic complexes, negative ion detection, and multi-stage tandem mass spectrometry capabilities at unit mass resolution for singly-charged ions and sub-unit mass resolution for multiply-charged species. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.