Purchase of a Quadrupole Ion Trap Mass Spectrometer

该奖项由化学研究仪器和设施 （CRIF）计划将协助大学化学系 华盛顿的四极离子阱质谱仪， 电喷雾离子化（ESI）和大气压化学 电离（APCI）接口，其将与液体接口 色谱仪。 该设备将加强一些领域的研究， 涉及不挥发性极性物质的高灵敏度电离的项目 化合物、肽、蛋白质、DNA缀合物、有机金属络合物， 负离子检测和多级串联质谱 单电荷离子和子单元的单位质量分辨率能力 多电荷物质的质量分辨率。 质谱（MS）是用于探测紧密结构的技术， 详细信息，并获得大量的分子组成， 有机、生物有机和有机金属分子。的加入 电喷雾技术将质谱的范围扩展到蛋白质和核酸 酸的分子量远远超过任何其他技术。使用 电喷雾电离结合高分辨率提供了 质谱分析的最新技术。它为化学家提供了 一个最强大的工具，可用于表征 化合物.在质谱分析中获得这种能力是 对许多领域的前沿研究至关重要， 化学.

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the University of Washington to acquire a quadrupole ion trap mass spectrometer equipped with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces, which will be interfaced to a liquid chromatograph. This equipment will enhance research in a number of projects involving highly sensitive ionization of involatile polar compounds, peptides, proteins, DNA conjugates, organometallic complexes, negative ion detection, and multi-stage tandem mass spectrometry capabilities at unit mass resolution for singly-charged ions and sub-unit mass resolution for multiply-charged species. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.