Upgrade of the UW Chemistry Department NMR Facility

有了化学研究仪器和设施（CRIF）计划的这一奖项，华盛顿大学化学系将升级他们的NMR设施。该设备将使研究人员能够进行以下研究：a）确定蛋白质结构和动力学; B）用过渡金属络合物使烷烃官能化; c）过渡金属络合物的合成和反应性; d）金属介导的氧化化学; e）DNA的快速局部角运动和缓慢构象变化; f）蛋白质和药物对RNA的识别。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对基础合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Washington will upgrade their NMR facilities. This equipment will enable researchers to carry out research on a) the determination of protein structure and dynamics; b) alkane functionalization with transition metal complexes; c) synthesis and reactivity of transition metal hydrides; d) metal mediated oxidation chemistry; e) rapid local angular motions and slow conformational changes in DNA; and f) RNA recognition by proteins and drugs. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in fundamental synthetic organic chemistry and biochemistry.