Cell Migration in Three-Dimensional Polymer Gels

9710313首席研究员萨尔茨曼建议合成具有选定化学和结构特征的聚合物材料，并使用这些材料来研究细胞迁移和细胞生长的机制。PI将研究分散在合成聚合物中的人类白细胞和神经组织细胞的细胞行为变化，在合成聚合物中，孔结构以及化学成分发生了系统的变化。通过使用各种聚合物材料，PI将检验这样一个假设，即最佳的细胞迁移需要环境在有限和可定义的范围内具有物理化学特征(孔径大小、粘附性、变形性)。***

9710313 Saltzman The Principal Investigator (PI) proposes to synthesize polymeric materials with a selected range of chemical and structural features, and use these materials to examine the mechanisms for cell migration and cell growth. The PI will study changes in cell behavior for human leukocytes and nervous tissue cells dispersed within the synthetic polymers in which the pore architecture as well as the chemical composition is systematically changed. By using a variety of polymeric materials, the PI will test the hypothesis that optimal cell migration requires environments possessing physicochemical features (pore size, adhesion, deformability) within a restricted and definable range. ***