Cell Migration in Three-Dimensional Polymer Gels

三维聚合物凝胶中的细胞迁移

• 批准号: 9710313
• 负责人: William Saltzman
• 金额: $ 34.5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9710313&HistoricalAwards=false
• 关键词: Cell; Migration; Three; Dimensional; Polymer

9710313 Saltzman The Principal Investigator (PI) proposes to synthesize polymeric materials with a selected range of chemical and structural features, and use these materials to examine the mechanisms for cell migration and cell growth. The PI will study changes in cell behavior for human leukocytes and nervous tissue cells dispersed within the synthetic polymers in which the pore architecture as well as the chemical composition is systematically changed. By using a variety of polymeric materials, the PI will test the hypothesis that optimal cell migration requires environments possessing physicochemical features (pore size, adhesion, deformability) within a restricted and definable range. ***

9710313 Saltzman主要研究者（PI）建议合成具有选定范围的化学和结构特征的聚合物材料，并使用这些材料来检查细胞迁移和细胞生长的机制。 PI将研究分散在合成聚合物中的人白细胞和神经组织细胞的细胞行为变化，其中孔结构以及化学组成发生了系统性变化。 通过使用各种聚合物材料，PI将检验以下假设：最佳细胞迁移需要在有限和可定义范围内具有理化特征（孔径、粘附性、变形性）的环境。 ***