Designer Path for Guided Cell Migration and Development in Three Dimensional Tissue Culture Gels

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9308527 Hu This project is to develop a method of creating a defined path for cell migration and tissue development in three dimensional structures such as gels. The results of this research would be very important to tissue engineering and developmental biology. One application of tissue engineering would be the production of artificial tissue, eg. artificial liver or pancreas tissue. Photoactivated reactions are to be used to covalently couple extracellular matrix or other cell adhesion molecules to a three dimensional substratum to define the path for cell migration or development. The position of the covalent coupling is defined by the cross point of two laser beams. The size, geometry, and trajectory of molecular deposition can be generated by controlling the scanning path of each laser beam. ***