A New Phase Transfer and Palladium(0) Catalyzed Method

这项授予明尼苏达大学的初学者奖金支持乔治·奥多尔蒂教授的研究。本研究针对的是一种新的相转移和钯(0)催化的方法将氟-18放射性同位素引入到具有生物重要性的分子中。感兴趣的反应是钯(0)催化的氟化物与不同的烯丙基碳酸酯的烯丙化反应。这种将氟引入有机底物的方法可能会取代需要昂贵、有毒和爆炸性试剂的旧方法，从而产生显著的环境效益。这项研究的目的是开发一种非常方便和干净的程序，可以用于正电子发射断层扫描，这是一种能够对生物系统中的小体积进行研究的技术。最终的应用将是研究分子在膜中的运动和其他细胞内事件。？┴？╝，：安源？╝？│`│%`？/╝？│`│%╣│║？%`/%，`安元？/元╣/┤┤╣元╣？元？│/╝▓？│？元/╣/┤╣？╝？╝？安元？/元？╝？/元？╣└？、`、元？╣？/元？┤？？╝？│？元/╣元╝？/%，`？？%╣，？┤元？╝┴╣元？元？╝？？║/│？╝？┴？╣│？╣？╝？/？元？╝_/║%//╝_？？▓？？╝？？┤╝╣？？│/└╣元`？元？╣？╝╣？╝║？│，安元└/╝╣？╣？╣：安元？安元？/元？_╝？/元？_│？/？？(？╝？？▓？╝/元？？元╝┐│元┐╝？│/▓？？╝_？┤▓`%╣，╣？╝？│`│%╣？╝？？元？？/原媛？？│？元/╣┐║元？┐╝║？│，安元？？│？_║？┐┤？│/▓？/┤？元？%？%/╝？

This starter grant award to the University of Minnesota supports the research of Professor George O'Doherty. The research is directed toward a new phase transfer and palladium(0) catalyzed method for the introduction of fluorine-18 radioisotopes into biologically important molecules. The reaction of interest is a palladium(0) catalyzed allylation of fluoride using various allyl carbonates. This method for introduction of fluorine to organic substrates may replace older methods that require expensive, toxic, and explosive reagents, resulting in significant environmental benefits. The research aims at developing a procedure that is so expedient and clean that it can be used for positron emission tomography, a technique which enables the investigation of small volumes in biological systems. The ultimate application would be study of the movements of molecules through membranes and other intra-cellular events. ¢ ┴?╝, ºÁ¥Á╝?│`│%`Á¢ /╝Á │`│%╣│ ║?%`/%,`Á¢ ¥©/¥ ╣ /┤┤╣¥╣? ¥? │/╝▓? │?¥/╣ / ┤╣ÂÂÁ╝Á¥ Á%Á_Á¥ ?╝ ©Á¥Á╝?/¥?_ ¼©Á ¢`¢¥Á_¢ ╣└Á¢¥╣À/¥Á┤ ©Á╝Á │?¥/╣ ¥©╝ÁÁ /%,`Á¢ %╣,Á┤ ¥?ÀÁ¥©Á╝ ┴╣¥© ¥©╝ÁÁ ¢║/│Á╝¢ ?Á ? ┴©╣│© ╣¢ ¥©Á ©Á¥Á╝?/¥?_ ¥? Â?╝_ / ║%//╝ _Á_▓Á╝Á┤ ╝╣À ¼©Á │/└╣¥` ? ¥©╣¢ ╝╣À ?╝ ║?│,Á¥ └/╝╣Á¢ ╣ ¢╣:Á /¢ ¥©Á ©Á¥Á╝?/¥?_ │©/ÀÁ¢ (?╝Á Á%/▓?╝/¥Á ¢¥╝┐│¥┐╝Á¢ │/ ▓Á Â?╝_Á┤ ▓` %╣,╣À ©Á¥Á╝?│`│%╣Á¢ ¥?ÀÁ¥©Á╝ ¢? ¥©/¥ ¥©Á` │?¥/╣ ┐║ ¥? Â?┐╝ ║?│,Á¥¢ ¼©Á │?_║?┐┤¢ │/ ▓Á _/┤Á ╣ / │?¥╝?%%Á┤ ┴/` /┤ ▓┐╣%¥ ┐║ ¥? %/╝ÀÁ╝ ¢¥╝┐│¥┐╝Á¢ ¥©/¥ ©/└Á │?┤┐│¥╣À /┤ %╣╗┐╣┤ │╝`¢¥/%%╣Á ║╝?║Á╝¥╣Á¢