A New Phase Transfer and Palladium(0) Catalyzed Method

这笔启动基金将授予明尼苏达大学，以支持乔治·奥多尔蒂教授的研究。该研究的方向是一种新的相转移和钯(0)催化方法，用于将氟-18放射性同位素引入生物学上重要的分子。感兴趣的反应是钯(0)催化氟烯丙基化使用各种烯丙基碳酸酯。这种将氟引入有机基质的方法可以取代需要昂贵、有毒和易爆试剂的旧方法，从而产生显著的环境效益。这项研究的目的是开发一种方便和清洁的程序，它可以用于正电子发射断层扫描，这是一种能够研究生物系统中小体积的技术。最终的应用将是研究分子通过膜的运动和其他细胞内事件。¢┴吗?╝,º¥╝?│‘│% ’ Á¢/ Á│'│%╣│% ‘ /%, ’ Á¢¥©/¥╣/¥吗?│/╝▓吗?│吗?¥/职权范围/职权范围ÂÂÁ ÂÂÁ Á¥Á%Á_Á¥？╝©¥╝? /¥吗?_¼©Á¢'¢¥Á_¢职权范围Á¢职权范围À/¥Á¥/╣¥©ÁÁ /%, ' Á¢%╣，Á <e:1>¥？ÀÁ¥©Á萨拉萨拉线¥©¥©萨拉萨拉线ÁÁⅷ/│Áⅷ？一个吗?Â→©╣│©╣¢¥©Á©Á¥Á ？/¥？_¥吗?一个吗?￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥￥Â¥©职权范围￠职权范围À ？╝║吗?│,¥└/╝╣一¢╣¢╣:A /¢¥©一个©¥╝? /¥吗?_│©/ÀÁ¢（?）╝% /▓吗?0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00.cn _Á│烧句子' %╣，╣À©Á¥Á .cn ？│“│%╣¢¥吗?AA¥©一╝¢吗?¥©/¥¥©Á’│？¥/ ？一个吗?┐╝║吗?│，Á¥¢¼©Á│？_ ？│¢│/烧烧Á _/│Á╣/│？¥？%%Á / ‘ / ’% /╝AA╝¢¥╝┐│¥┐╝一¢¥©/¥©/└│吗?→││¥À /│%特长→→│││￥/%%特长→Á║一╝¥╣¢

This starter grant award to the University of Minnesota supports the research of Professor George O'Doherty. The research is directed toward a new phase transfer and palladium(0) catalyzed method for the introduction of fluorine-18 radioisotopes into biologically important molecules. The reaction of interest is a palladium(0) catalyzed allylation of fluoride using various allyl carbonates. This method for introduction of fluorine to organic substrates may replace older methods that require expensive, toxic, and explosive reagents, resulting in significant environmental benefits. The research aims at developing a procedure that is so expedient and clean that it can be used for positron emission tomography, a technique which enables the investigation of small volumes in biological systems. The ultimate application would be study of the movements of molecules through membranes and other intra-cellular events. ¢ ┴?╝, ºÁ¥Á╝?│`│%`Á¢ /╝Á │`│%╣│ ║?%`/%,`Á¢ ¥©/¥ ╣ /┤┤╣¥╣? ¥? │/╝▓? │?¥/╣ / ┤╣ÂÂÁ╝Á¥ Á%Á_Á¥ ?╝ ©Á¥Á╝?/¥?_ ¼©Á ¢`¢¥Á_¢ ╣└Á¢¥╣À/¥Á┤ ©Á╝Á │?¥/╣ ¥©╝ÁÁ /%,`Á¢ %╣,Á┤ ¥?ÀÁ¥©Á╝ ┴╣¥© ¥©╝ÁÁ ¢║/│Á╝¢ ?Á ? ┴©╣│© ╣¢ ¥©Á ©Á¥Á╝?/¥?_ ¥? Â?╝_ / ║%//╝ _Á_▓Á╝Á┤ ╝╣À ¼©Á │/└╣¥` ? ¥©╣¢ ╝╣À ?╝ ║?│,Á¥ └/╝╣Á¢ ╣ ¢╣:Á /¢ ¥©Á ©Á¥Á╝?/¥?_ │©/ÀÁ¢ (?╝Á Á%/▓?╝/¥Á ¢¥╝┐│¥┐╝Á¢ │/ ▓Á Â?╝_Á┤ ▓` %╣,╣À ©Á¥Á╝?│`│%╣Á¢ ¥?ÀÁ¥©Á╝ ¢? ¥©/¥ ¥©Á` │?¥/╣ ┐║ ¥? Â?┐╝ ║?│,Á¥¢ ¼©Á │?_║?┐┤¢ │/ ▓Á _/┤Á ╣ / │?¥╝?%%Á┤ ┴/` /┤ ▓┐╣%¥ ┐║ ¥? %/╝ÀÁ╝ ¢¥╝┐│¥┐╝Á¢ ¥©/¥ ©/└Á │?┤┐│¥╣À /┤ %╣╗┐╣┤ │╝`¢¥/%%╣Á ║╝?║Á╝¥╣Á¢