De Novo Synthesis of Oligosaccharides via Palladium Catalysis

通过钯催化从头合成低聚糖

• 批准号: 0415469
• 负责人: George ODoherty
• 金额: $ 35.5万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415469&HistoricalAwards=false
• 关键词: De; Novo; Synthesis; Oligosaccharides; via

The focus of this research involves the development of asymmetric synthetic methods for the production of a variety of oligosaccharides. The reaction strategy is centered on the use of the Achmatowicz rearrangement for the preparation of pyranones in concert with palladium-catalyzed glycosylation. The methodology will lead to the production of new and hitherto unknown unnatural oligosaccharides having interesting materials and biological properties.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. George A. O'Doherty in the Department of Chemistry at West Virginia University. Dr. O'Doherty will focus his work on developing methodology for asymmetric synthesis of oligosaccharides. The methodology will allow for the facile incorporation of simple sugars into oligosaccharide motifs thus leading to the discovery of new structures possessing a wide range of functions. The broader impact of the work is in the area of materials science as well as the pharmaceutical industry. Further, the project presents an excellent vehicle for the training of both undergraduate and graduate students.

本研究的重点是开发用于生产各种寡糖的不对称合成方法。 反应策略集中在使用Achmatowicz重排与钯催化的糖基化反应制备吡喃酮。 该方法将导致生产新的和迄今未知的非天然寡糖具有有趣的材料和生物学特性。有了这个奖项，有机和高分子化学计划是支持乔治的研究。西弗吉尼亚大学化学系的奥多尔蒂说。 O'Doherty博士将专注于开发寡糖的不对称合成方法。 该方法将允许简单的糖到寡糖基序，从而导致具有广泛的功能的新结构的发现容易纳入。这项工作的更广泛影响是在材料科学领域以及制药行业。 此外，该项目为本科生和研究生的培训提供了一个很好的工具。