De Novo Asymmetric Synthesis of Natural and Unnatural Carbohydrate Motifs

天然和非天然碳水化合物基序的从头不对称合成

• 批准号: 1213596
• 负责人: George ODoherty
• 金额: $ 30万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213596&HistoricalAwards=false
• 关键词: De; Novo; Asymmetric; Synthesis; Natural

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor George A. O'Doherty of the Department of Chemistry and Chemical Biology at Northeastern University will explore the development of methods for the de novo synthesis of natural and unnatural oligosaccharide structural motifs. While there exist many chemical and biochemical methods for the construction and isolation of the most common oligosaccharide motifs, there is a dearth of methods for oligosaccharide made up of unnatural sugars. The O'Doherty group plans to develop innovative methods to address this need. The planned approach revolves around the use of asymmetric and diastereoselective catalytic reactions for the highly stereoselective construction of oligosaccharide motifs. This work could lead to the discovery of new methods for the efficient synthesis of oligosaccharides that are difficult to obtain. It is expected that these new methods will allow for a more environmentally benign access to these important structural motifs. In addition, the development of these approaches will enable further biological study of an important class of biomolecules, which in turn could lead to new therapies for the treatment of a myriad of carbohydrate related diseases. In addition, this project will provide excellent training of students from a wide range of backgrounds (e.g., high school, undergraduate, graduate and post-doctoral students, including students from groups historically underrepresented in the sciences).

在这个由化学系化学合成计划资助的项目中，东北大学化学和化学生物学系的乔治·A·奥多尔蒂教授将探索从新合成天然和非天然寡糖结构基序的方法。虽然有许多化学和生化方法来构建和分离最常见的低聚糖基序，但缺乏由非天然糖组成的低聚糖的方法。O‘Doherty团队计划开发创新的方法来满足这一需求。计划中的方法围绕着使用不对称和非对映选择性催化反应来构建高度立体选择性的低聚糖基序。这项工作可能导致发现有效合成难以获得的低聚糖的新方法。预计这些新方法将使人们能够更加无害环境地利用这些重要的结构主题。此外，这些方法的发展将使对一类重要生物分子的进一步生物学研究成为可能，这反过来可能导致治疗无数与碳水化合物相关的疾病的新疗法。此外，该项目将为来自各种背景的学生(例如，高中生、本科生、研究生和博士后，包括在科学界历来代表性不足的学生)提供出色的培训。