Investigating the Dallos/Evans, TWAmp, and FEM Models of Cochlear Mechanisms

研究人工耳蜗机构的 Dallos/Evans、TWAmp 和 FEM 模型

• 批准号: 9712264
• 负责人: Lisa Shatz
• 金额: $ 1.78万
• 依托单位: Suffolk University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9712264&HistoricalAwards=false
• 关键词: Investigating; Dallos; Evans; TWAmp; FEM

9712264 Shatz The PI plans to learn more about several models of inner ear function. The aim of this research is to provide the PI with background in current models of the electromotive effects in cochlear mechanics, including the Traveling Wave amplifier (TWAmp) Dallos/Evans and finite element (FEM) models. The TW Amp models the cochlear via two coupled transmission lines. This model simulates a large range of experimental observations but needs a physiological equivalent. The FEM model fails to represent the electrical properties of the cochlear; if only models its mechanical properties. The Dallos/Evans theory purposes a mechanism by which the outer hair cells, the main transducting components of the inner ear, are stimulated via the organ of Corti. None of these models individually serves as a comprehensive representation of human cochlear function. The applicant therefore intends to study all three, with longer term goals of using the TWAmp model to test the Dallos/Evans theory, improving the FEM model to incorporate electrical mechanisms, and developing an understanding of the physiological equivalent of the TWAmp. ***

9712264 Shatz PI计划了解更多关于内耳功能的几种模型。 本研究的目的是为PI提供耳蜗力学中电动效应的当前模型的背景，包括行波放大器（TWENTS）Dallos/Evans和有限元（FEM）模型。 TW模拟器通过两条耦合的传输线对耳蜗进行建模。 该模型模拟了大范围的实验观察，但需要生理等效。 FEM模型未能代表耳蜗的电特性;如果仅对其机械特性进行建模。 Dallos/Evans理论的目的是一种机制，通过这种机制，外毛细胞（内耳的主要转导成分）通过Corti器官受到刺激。 这些模型都不能单独作为人类耳蜗功能的全面代表。 因此，申请人打算研究所有这三种，长期目标是使用TWITAL模型来测试Dallos/Evans理论，改进FEM模型以纳入电机制，并了解TWITAL的生理等效物。 ***