RUI: Investigating the Effect of Hair Bundle Hydrodynamics in the Inner Ear

RUI：研究毛束流体动力学对内耳的影响

• 批准号: 0099753
• 负责人: Lisa Shatz
• 金额: $ 6.32万
• 依托单位: Suffolk University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0099753&HistoricalAwards=false
• 关键词: RUI; Investigating; Effect; Hair; Bundle

Shatz0099753An important goal of this research is to understand the relationship between the morphology of inner ear hair bundle structures and their functionality; in particular, how the size and shape affects their response to stimuli of different frequencies. Another goal is to understand the role that an overlying membrane has in hair cell sensitivity. Hair bundles of hearing organs are usually topped by an overlying membrane called the tectorial membrane. Comparing the hydrodynamics of a model which represents an overlying membrane to one that does not should elucidate the role of an overlying membrane in hair cell sensitivity. The principal investigator previously investigated the hydrodynamics of a single hair bundle as a two-dimensional flap and as a three-dimensional hemispheroid. The 3-D analysis indicated that the 2-D model does not adequately represent hair bundle dynamics at low frequencies. This new research project is designed to extend the hemispheroid model in two directions: to include mid-frequencies, and to analyze a model with an overlying membrane in the low and high frequency regions. Students are to participate in this research in several ways: by comparing the results of different methods of solving for the distribution of the fundamental solutions; by animating the motion of the hair bundles and surrounding fluid; by studying the singularity method; studying the features of neural tuning curves. The research will enhance the students' understanding in the areas of fluid flows, numerical analysis, ear physiology, and computer programming. Results from the research are expected to contribute to the knowledge base of auditory science and also to numerical modeling of fluids. In the field of micro-mechanics the new knowledge may prove useful in developing micro-mechanical transducers of sound and motion.

本研究的一个重要目标是了解内耳毛束结构的形态与其功能之间的关系;特别是，大小和形状如何影响它们对不同频率刺激的反应。另一个目标是了解覆盖膜在毛细胞敏感性中的作用。听觉器官的毛束通常由一层覆盖膜覆盖，称为盖膜。将代表覆盖膜的模型的流体动力学与不应阐明覆盖膜在毛细胞敏感性中的作用的模型的流体动力学进行比较。主要研究者以前调查了一个单一的头发束作为一个二维皮瓣和作为一个流体动力学 三维半球体。3-D分析表明，2-D模型不能充分代表发束动力学在低频率。这个新的研究项目旨在两个方向扩展半球模型：包括中频，并分析在低频和高频区域覆盖膜的模型。 学生将以几种方式参与这项研究：通过比较不同方法的结果来求解基本解的分布;通过动画显示头发束和周围流体的运动;通过研究奇异性方法;研究神经调谐曲线的特征。 这项研究将提高学生在流体流动，数值分析，耳生理学和计算机编程领域的理解。研究结果有望为听觉科学的知识基础和流体的数值模拟做出贡献。在微机械领域，这些新知识可能有助于开发声音和运动的微机械传感器。