CONFERENCE: Mechanisms of Secretion, Woods Hole, MA, September 4-6, 1997

IBN-9722886分泌机制（会议）PI: Thomas F.J. Martin， University of Wisconsin联合PI: George J. Augustine， Duke University本申请为一个关于分泌机制的国际研究会议寻求资助。神经和内分泌系统的功能需要细胞间的化学通讯。神经递质在神经细胞之间架起桥梁，而传递到血液中的蛋白质激素则触发各种组织的生理过程。这两种类型的化学信号都是通过一个相似的过程从细胞中释放出来的，这个过程包括分泌囊泡与质膜的融合。了解这一膜融合过程及其调控是许多活跃研究的焦点。在过去的3-4年里，巨大的进步导致了神经递质释放所需的几种蛋白质的鉴定。发现非常相似的蛋白质参与许多其他胞内膜融合事件表明，共同的原则支配膜融合。本次会议的目的是将这一研究前沿的科学家聚集在一起，就最近出现的膜融合的一般原理进行生动和及时的思想交流，并促进从生化，分子和遗传研究到理解生理机制的见解的转化。该会议由普通生理学家协会主办，将于1997年9月4日至6日在马萨诸塞州伍兹霍尔的海洋生物实验室举行，是一个小型会议（约250人参加）。除了5场20位演讲嘉宾和一位主题演讲嘉宾外，3场会议将展示海报，2场会议将安排8场简短的演讲。为10名研究生/博士后提供住宿奖励，以鼓励年轻科学家的参与。会议将涵盖：分泌的第二信使调节，参与分泌的蛋白质，分泌中的囊泡池，膜融合机制和内吞作用。James Rothman博士将发表题为“细胞内蛋白质运输的机制和机制”的主题演讲。

IBN-9722886 Mechanisms of Secretion (Conference) PI: Thomas F.J. Martin, University of Wisconsin co-PI: George J. Augustine, Duke University This application seeks funding for an international research conference on Mechanisms of Secretion. Function in the nervous and endocrine systems requires chemical communication between cells. Neurotransmitters bridge the gap between nerve cells whereas protein hormones delivered to the bloodstream trigger physiological processes in various tissues. Both types of chemical signals are released from cells by a similar process that involves the fusion of secretory vesicles with the plasma membrane. Understanding this process of membrane fusion and its regulation is the focus of much active research. Dramatic progress over the last 3-4 years led to the identification of several proteins that are required for neurotransmitter release. The discovery that very similar proteins are involved in many other intracellular membrane fusion events indicates that common principles govern membrane fusion. The goal of this conference is to bring together scientists at the cutting edge of this research for a lively and timely exchange of ideas on the recently- emergent general principles in membrane fusion, and to promote a translation of insights from biochemical, molecular and genetic research to understanding physiological mechanisms. The conference is sponsored by the Society for General Physiologists and will be held September 4-6, 1997 in Woods Hole, MA at the Marine Biological Laboratory as a small meeting (~250 participants). In addition to 20 speakers in 5 sessions plus a keynote speaker, posters will be presented at 3 sessions, and 8 short talks will be programmed in 2 New Ideas sessions. Accomodation awards to 10 grad students/postdocs will encourage participation by young scientists. Sessions will cover: second messenger regulation of secretion, proteins involved in secretion, vesicle pools in secretion, membrane fusion mechanisms and endocytosis. Dr. James Rothman will deliver the keynote address on "Mechanisms and machinery of intracellular protein transport."