Central Components of Sympathetic Pathways

摘要PI: Caron Dean-Bernhoft， Ph.D.提案号：IBN-9723348由于身体的需求并不总是相同的，在许多情况下，心脏和血管维持血压的变化是不同的。例如，在对抗中，心率和流向活动肌肉的血流量必须上升，但流向肾脏的血流量可能会减少。另一方面，当天气变冷时，流向皮肤的血液会减少，而流向内脏的血液会增加，以保持热量。这些心率和血流的变化是由大脑中一个叫做RVLM的特定部位调节的。本研究探讨了在不同的行为状态下，RVLM的这些神经细胞如何协调神经活动来调节心血管系统。特别注意的是该区域细胞释放的化学物质的特征，这些化学物质调节该中心的活动，从而改变心血管活动的模式。这项研究的结果有助于了解在不同或紧急情况下如何调节血流和血压以满足身体的需要。这些信息是深入了解如何控制血压的基础。

Lay Abstract PI: Caron Dean-Bernhoft, Ph.D. Proposal Number: IBN-9723348 The changes that take place in the heart and blood vessels to maintain blood pressure under a number of conditions are different, since the requirements of the body are not always the same. For example, during confrontations, heart rate and blood flow to the active muscles must go up but blood flow to the kidney can be reduced. On the other hand, when it gets cold, blood flow to the skin decreases while flow to internal organs increases to retain heat. These types of changes in heart rate and blood flow are regulated by a specific part of the brain called the RVLM. This study examines how these nerve cells of the RVLM coordinate nerve activity to regulate the cardiovascular system during different behavioral states. Particular attention is paid to the characteristics of the chemical substances released from cells in this area that modulate the activity of this center, and thus change the pattern of cardiovascular activity. The results from this study contribute to understanding how blood flow and blood pressure are adjusted to meet the needs of the body under different or emergency situations. Such information is fundamental to a deeper understanding of how blood pressure is controlled.