ERA NanoSci - Nanocommunication: How virus particles convince cells to let them inside
ERA NanoSci - 纳米通讯:病毒颗粒如何说服细胞让它们进入
基本信息
- 批准号:118558436
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2009
- 资助国家:德国
- 起止时间:2008-12-31 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Eukaryotic viruses replicating in the nucleus must pass two barriers, the plasma membrane and the nuclear envelope, to deliver their genome to a compartment allowing replication, and to initiate an infection. Viral nanomachines have evolved to efficiently interface with and overcome these barriers. To arrive at a thorough understanding of this molecular interfacing we will address the following questions: i) What is the mechanochemistry of contact formation between an enveloped viral particle and a cell membrane? How does interfacing between a viral and a host membrane trigger capsid release in the cytosol? ii) What are the physical, structural and chemical principles underlying functional coupling between viral capsids and nuclear pore complexes allowing access to the nucleus? How is the release of the viral genome triggered? Dissecting and describing these molecular interfacing mechanisms will provide researchers with tools to design nano-objects that can enter and influence cells.
在细胞核中复制的真核病毒必须通过两个屏障,即质膜和核膜,将其基因组传递到允许复制的隔室,并启动感染。病毒纳米机器已经进化到有效地与这些障碍相互作用并克服这些障碍。为了彻底理解这种分子界面,我们将解决以下问题:i)包膜病毒颗粒和细胞膜之间接触形成的机械化学是什么?病毒和宿主细胞膜之间的界面如何触发衣壳在胞质溶胶中的释放?ii)病毒衣壳和核孔复合物之间的功能耦合背后的物理、结构和化学原理是什么?病毒基因组的释放是如何触发的?剖析和描述这些分子界面机制将为研究人员提供设计可以进入和影响细胞的纳米物体的工具。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Amphipathic Helix of Adenovirus Capsid Protein VI Contributes to Penton Release and Postentry Sorting
- DOI:10.1128/jvi.02257-14
- 发表时间:2015-02-01
- 期刊:
- 影响因子:5.4
- 作者:Martinez, Ruben;Schellenberger, Pascale;Wodrich, Harald
- 通讯作者:Wodrich, Harald
The Structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex Reveals the Protein-Membrane and Lateral Protein-Protein Interaction
- DOI:10.1016/j.str.2013.05.018
- 发表时间:2013-08-06
- 期刊:
- 影响因子:5.7
- 作者:Maurer, Ulrike E.;Zeev-Ben-Mordehai, Tzviya;Gruenewald, Kay
- 通讯作者:Gruenewald, Kay
A precipitation-based assay to analyze interactions of viral particles with cytosolic host factors.
基于沉淀的分析病毒颗粒与胞质宿主因子相互作用的方法
- DOI:10.1007/978-1-4939-0428-0_13
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Radtke K;F Anderson ;B Sodeik
- 通讯作者:B Sodeik
Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B
- DOI:10.1073/pnas.1523234113
- 发表时间:2016-03
- 期刊:
- 影响因子:0
- 作者:T. Zeev-Ben-Mordehai;D. Vasishtan;A. Durán;A. Durán;B. Vollmer;P. White;A. P. Pandurangan;C. A. Siebert;M. Topf;K. Grünewald
- 通讯作者:T. Zeev-Ben-Mordehai;D. Vasishtan;A. Durán;A. Durán;B. Vollmer;P. White;A. P. Pandurangan;C. A. Siebert;M. Topf;K. Grünewald
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Professor Dr. Kay Grünewald其他文献
Professor Dr. Kay Grünewald的其他文献
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{{ truncateString('Professor Dr. Kay Grünewald', 18)}}的其他基金
Structural and functional analysis of Cav1.2 mediated PM-ER contacts in the postsynaptic membrane
突触后膜中 Cav1.2 介导的 PM-ER 接触的结构和功能分析
- 批准号:
416436443 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Research Units
Structural analysis of herpesvirus assembly by cryo electron tomography
冷冻电子断层扫描疱疹病毒组装的结构分析
- 批准号:
13491680 - 财政年份:2005
- 资助金额:
-- - 项目类别:
Priority Programmes
Structure and dynamics of protein complexes in the course of herpesvirus cellular infection analyzed by cryo electron tomography
冷冻电子断层扫描分析疱疹病毒细胞感染过程中蛋白质复合物的结构和动态
- 批准号:
5355607 - 财政年份:2001
- 资助金额:
-- - 项目类别:
Independent Junior Research Groups
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