Beamline X9A: Acquisition of Instrumentation for Macromolecular Crystallography

该提案寻求资金，用于在布鲁克海文国家实验室的国家同步加速器光源（NSLS）的X9 A光束线上完成最先进的弯曲磁铁蛋白质晶体学站。该计划包括购买光束线光学组件（即，该系统还包括一个CCD探测器和相关的自动化和计算硬件，用于快速有效地收集和处理数据。该设施将为阿尔伯特爱因斯坦医学院（AECOM），洛克菲勒大学（RU）和斯隆-凯特琳研究所（SKI）的晶体学社区提供每年170天的高通量，可调谐同步辐射，并将允许现有项目的快速进展，以及新的结构问题的启动和及时完成。此外，该设施将通过NSLS通用用户程序向全国范围内的蛋白质晶体学社区提供60天的射束时间，该程序要求通过NSLS管理的同行评审过程分配总射束时间的25%。

This proposal seeks funding for the completion of a state of the art, bending magnet, protein crystallography station on the X9A beamline of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratories. The plan includes the purchase of the beamline optical components (i.e., monochromator and mirror) as well as a CCD detector and associated automation and computing hardware for rapid and efficient data collection and reduction. This facility will provide the crystallographic communities at the Albert Einstein College of Medicine (AECOM), Rockefeller University (RU) and the Sloan-Kettering Institute (SKI) with 170 days of access per year to high flux, tunable synchrotron radiation, and will allow for rapid progress on existing projects, as well as the initiation and timely completion of new structural problems. In addition, this facility will provide 60 days of beam time to the protein crystallography community nationwide through the NSLS General User program, which requires that 25% of the total beam time be distributed through a peer reviewed process administered by NSLS.