SYNCHROTRON CRYSTALLOGRAPHY BEAMLINE X9A STRUCTURE FUNCTION STUDIES

同步加速器晶体学光束线 X9A 结构功能研究

• 批准号: 6205790
• 负责人: STEVE ALMO
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205790
• 关键词: biological products; biomedical resource; enzymes; lipids; nucleic acids; proteins; spectrometry; synchrotrons; technology /technique

High-resolution x-ray crystallography has had unparalleled impact on the course of biological and biomedical research. Structural information is providing exquisite detail about the assembly and control of macromolecular complexes and the mechanisms of macromolecular function. Future advances in biological and biomedical science require an ever-expanding structural data base to keep pace with the rapidly growing body of biochemical and genetic data. Given the unprecedented volume of data accruing from the genome sequencing projects, there is no period in history that will benefit as much from an expansion of structural resources and methodologies. This project is directly taking up this challenge by expanding the national and worldwide MAD data collection facilities and in developing new technologies for efficient and rapid de novo structure solution by MAD crystallography.

高分辨率的x射线晶体学已经产生了无与伦比的影响 生物学和生物医学研究的课程。 结构 信息提供了有关大会的精美细节， 大分子复合物的控制及其机理 大分子功能 生物和生物医学的未来进展 科学需要一个不断扩展的结构化数据库来跟上 快速增长的生物化学和基因数据。 给定 从基因组测序中积累的前所未有的数据量 历史上没有哪个时期能像现在这样 结构资源和方法的扩展。 这个项目 直接通过扩大国家和 全球MAD数据收集设施，并开发新的 通过MAD实现高效和快速的从头结构解决方案的技术 结晶学